2,2-二甲基-1,2-二氢喹啉合成路线 （共 11 条）
反应条件
3,3',3''-phosphinidynetris-benzenesulfonic acid tri-Na salt; palladium diacetate in ethanol; water T=80°C; 1.5 h;
参考文献
Yokoyama, Yuusaku; Takagi, Noriko; Hikawa, Hidemasa; Kaneko, Satoru; Tsubaki, Natsume; Okuno, Hiroaki
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 662 - 668
反应条件
copper(l) chloride in tetrahydrofuran 14 h; Heating;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
copper(l) chloride in tetrahydrofuran
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US6017924 A1, 2000 ;
反应条件
1: 79 percent / 3,3',3''-phosphinidynetris-benzenesulfonic acid tri-Na salt; K2CO3 / Pd(OAc)2 / H2O; ethanol / 3 h / 100 °C 2: 42 percent / 3,3',3''-phosphinidynetris-benzenesulfonic acid tri-Na salt / Pd(OAc)2 / H2O; ethanol / 1.5 h / 80 °C View Scheme
参考文献
Yokoyama, Yuusaku; Takagi, Noriko; Hikawa, Hidemasa; Kaneko, Satoru; Tsubaki, Natsume; Okuno, Hiroaki
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 662 - 668
反应条件
1: 79 percent / 3,3',3''-phosphinidynetris-benzenesulfonic acid tri-Na salt; K2CO3 / Pd(OAc)2 / H2O; ethanol / 3 h / 100 °C 2: 42 percent / 3,3',3''-phosphinidynetris-benzenesulfonic acid tri-Na salt / Pd(OAc)2 / H2O; ethanol / 1.5 h / 80 °C View Scheme
参考文献
Yokoyama, Yuusaku; Takagi, Noriko; Hikawa, Hidemasa; Kaneko, Satoru; Tsubaki, Natsume; Okuno, Hiroaki
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 662 - 668
反应条件
1: 67 percent / 1,1'-bis(diphenylphosphino)ferrocene; K2CO3 / Pd(OAc)2 / H2O; toluene / 3 h / 100 °C 2: 42 percent / 3,3',3''-phosphinidynetris-benzenesulfonic acid tri-Na salt / Pd(OAc)2 / H2O; ethanol / 1.5 h / 80 °C View Scheme
参考文献
Yokoyama, Yuusaku; Takagi, Noriko; Hikawa, Hidemasa; Kaneko, Satoru; Tsubaki, Natsume; Okuno, Hiroaki
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 4-5 p. 662 - 668
反应条件
n-butyllithium 1.) Et2O, hexane, -65 deg C, 10 min, 2.) Et2O, hexane, RT, 2 h; Yield given. Multistep reaction;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 99 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 4 h 2: 57 percent / HNO3, H2SO4 / 0.25 h / -5 °C 3: H2 / 10percent Pd/C / ethanol; ethyl acetate / 6 h View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
hydrogen; palladium on activated charcoal in ethanol; ethyl acetate
4 h;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
pyridine in dichloromethane
T=20°C;
参考文献
Williamson, Natalie M.; Ward, A. David
Tetrahedron, 2005 , vol. 61, # 1 p. 155 - 165
