4-(1-羟基-1-甲基乙基)-2-丙基-1H-咪唑-5-羧酸乙酯合成路线 （共 17 条）
反应条件
1: in tetrahydrofuran T=-10 - 0°C; 0.166667 h; 2: With water; ammonium chloride in tetrahydrofuran; dichloromethane
参考文献
Cadila Pharmaceuticals Limited
Patent: EP1916246 A2, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: With sulfuric acid T=40 - 50°C; 2: With sodium hydrogencarbonate in water; ethyl acetate Product distribution / selectivity;
参考文献
Shanghai Institute of Pharmaceutical Industry; Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP2374799 A1, 2011 ;
Location in patent: Page/Page column 9 ;
反应条件
in diethyl ether; dichloromethane T=10 - 15°C; 1 h;
参考文献
Yanagisawa, Hiroaki; Amemiya, Yoshiya; Kanazaki, Takuro; Shimoji, Yasuo; Fujimoto, Koichi; Kitahara, Yoshiko; Sada, Toshio; Mizuno, Makoto; Ikeda, Masahiro; Miyamoto, Shuichi; Furukawa, Youji; Koike, Hiroyuki
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 323 - 338
反应条件
methylmagnesium bromide in tetrahydrofuran
参考文献
US5616599 A1, ;
US 5616599 A
反应条件
1: With thionyl chloride Reflux; 2: With sodium hydrogencarbonate in water; ethyl acetate Product distribution / selectivity;
参考文献
Shanghai Institute of Pharmaceutical Industry; Zhejiang Hisun Pharmaceutical Co. Ltd.
Patent: EP2374799 A1, 2011 ;
Location in patent: Page/Page column 10 ;
反应条件
1: 86 percent / HCl / Ambient temperature 2: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 323 - 338
反应条件
1: 80 percent / 6N aq. HCl / 8 h / Heating 2: 86 percent / HCl / Ambient temperature 3: 95 percent / diethyl ether; CH2Cl2 / 1 h / 10 - 15 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 323 - 338
反应条件
1: dicyclohexyl-carbodiimide / acetone / 48 h / 20 °C 2: sodium hydroxide; water / acetone / Reflux 3: thionyl chloride / Reflux View Scheme
反应条件
1: sodium hydroxide; water / acetone / Reflux 2: thionyl chloride / Reflux View Scheme
反应条件
1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h 2: LiOH*H2O / dioxane; H2O / 20 h / Ambient temperature 3: 88 percent / K2CO3 / N,N-dimethyl-acetamide / 4 h / 20 - 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 1 p. 323 - 338
