5,6-二氢噻吩并[2,3-c]吡啶-7(4H)-酮合成路线 （共 8 条）
反应条件
1: With hydroxylamine hydrochloride; sodium acetate in methanol T=20°C; 2: T=130°C; 0.5 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/146758 A2, 2007 ;
Location in patent: Page/Page column 32-33 ;
WO 2007/146758 A2
反应条件
phosphorus pentoxide T=110°C; 3.75 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/146758 A2, 2007 ;
Location in patent: Page/Page column 33-34 ;
WO 2007/146758 A2
参考文献
Parcor
Patent: US4193997 A1, 1980 ;
反应条件
boron trifluoride diethyl etherate in dichloromethane T=20°C; Friedel-Crafts Acylation; 20 h; regioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 5 p. 965 - 971
反应条件
1.1: methanesulfonic acid; phosphorous pentoxide / 1 h / 20 °C 2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C 2.2: Polyphosphoric acid Polyphosphoric acid Polyphosphoric acid polyphosphoric acid / 2 h / 130 °C View Scheme
反应条件
1: sodium carbonate / chloroform / 0 - 20 °C 2: phosphorus pentoxide; trichlorophosphate / 3 h / 110 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 3, p. 466 - 469
反应条件
bromine; acetic acid T=0°C; 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/146758 A2, 2007 ;
Location in patent: Page/Page column 34 ;
WO 2007/146758 A2
