4’-[[1,4’-二甲基-2’-丙基(2,6’-联-1H-苯并咪唑)-1’-甲基]-[1,1’-联苯基]-2-羧酸叔丁酯合成路线 （共 10 条）
反应条件
1: in ethanol 0.5 h; 2: With sodium dithionite in ethanol; water T=50°C;
参考文献
ZAKLADY FARMACEUTYCZNE POLPHARMA SA
Patent: WO2009/123483 A1, 2009 ;
Location in patent: Page/Page column 18-19 ;
反应条件
potassium tert-butylate in N,N-dimethyl acetamide T=75 - 80°C; 3 h; Inert atmosphere;
参考文献
Kumar, A. Sanjeev; Ghosh, Samir; Mehta
Journal of Chemical Research, 2010 , # 2 p. 95 - 97
反应条件
1: chlorobenzene / 100 °C 2: fuming HNO3, 60percent H2SO4 / 0 °C 3: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 4: glacial CH3COOH / 1.5 h / Heating 5: 5.46 g / aq. NaOH / methanol / 2 h / Heating 6: 5.86 g / polyphosphoric acid / 20 h / 150 °C 7: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: fuming HNO3, 60percent H2SO4 / 0 °C 2: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 3: glacial CH3COOH / 1.5 h / Heating 4: 5.46 g / aq. NaOH / methanol / 2 h / Heating 5: 5.86 g / polyphosphoric acid / 20 h / 150 °C 6: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: H2 / 10percent Pd/C / methanol / 50 °C / 3750.3 Torr 2: glacial CH3COOH / 1.5 h / Heating 3: 5.46 g / aq. NaOH / methanol / 2 h / Heating 4: 5.86 g / polyphosphoric acid / 20 h / 150 °C 5: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: 5.46 g / aq. NaOH / methanol / 2 h / Heating 2: 5.86 g / polyphosphoric acid / 20 h / 150 °C 3: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: glacial CH3COOH / 1.5 h / Heating 2: 5.46 g / aq. NaOH / methanol / 2 h / Heating 3: 5.86 g / polyphosphoric acid / 20 h / 150 °C 4: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: 5.86 g / polyphosphoric acid / 20 h / 150 °C 2: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
1: 5.86 g / polyphosphoric acid / 20 h / 150 °C 2: 1.) t-BuOK / 1.) DMSO, RT, 30 min, 2.) DMSO, 14 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 25 p. 4040 - 4051
反应条件
trifluoroacetic acid in N,N-dimethyl-formamide 4 h;
参考文献
Kumar, A. Sanjeev; Ghosh, Samir; Mehta
Journal of Chemical Research, 2010 , # 2 p. 95 - 97
