1: sodium hydride / 6.5 h / 20 °C / |Inert atmosphere 2: potassium tert-butylate / diethyl ether / 2 h / 40 - 45 °C / |Inert atmosphere 3: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / water; dichloromethane / 20 °C 4: tetrakis(triphenylphosphine) palladium(0); morpholine / tetrahydrofuran / 20 °C 5: potassium carbonate; silver(I) acetate / 0.33 h / 90 - 100 °C 6: sodium methylate / methanol / 20 °C View Scheme

1.1: sodium hydride / paraffin oil / 6.5 h / 20 °C 2.1: potassium tert-butylate / diethyl ether / 2 h / 40 - 45 °C / |Inert atmosphere 3.1: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / water; dichloromethane / 5 h / 20 °C 4.1: morpholine; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 18 h / 20 °C / |Inert atmosphere; |Darkness 4.2: 0.3 h / 90 - 100 °C / |Inert atmosphere; |Darkness 5.1: sodium methylate; methanol / 1 h / 20 °C View Scheme