hydrogenchloride in methanol; water; acetone T=5 - 40°C; 4 h;

hydrogenchloride in pentan-3-one T=-10 - 10°C; 0.5 h; Product distribution / selectivity;

sulfuric acid

1: (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=-10 - 0°C; 2.5 h; 2: methanol in dichloromethane T=0 - 20°C; 2.5 h;

potassium carbonate in 1-methyl-pyrrolidin-2-one Product distribution / selectivity;