potassium cyanide; tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide 18 h; Inert atmosphere;

TiI4 in acetonitrile T=0 - 20°C; Reduction; 5.3 h;

benzaldehyde lyase from Pseudomonas fluorescens; thiamine diphosphate; magnesium chloride in dimethyl sulfoxide T=20°C; pH=7.0; 24 h; aq. phosphate bufferInert atmosphereEnzymatic reaction; optical yield given as percent ee;

1: With naphthalenyllithium in tetrahydrofuran T=20°C; 1 h; 2: With chloro-trimethyl-silane in tetrahydrofuran T=-78°C; 0.5 h; 3: With water in tetrahydrofuran T=0°C; Title compound not separated from byproducts;

benzaldehyde lyase from Pseudomonas fluorescens; thiamine diphosphate; magnesium chloride pH=7.0; aq. phosphate bufferEnzymatic reaction;

Multistep reaction;