乙基3-叠氮基-2-羟基-丙酸酯合成路线 （共 20 条）
反应条件
1: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 2: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 3: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 4: 100 percent / LiOH, H2O / ethanol / 20 °C 5: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 6: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
sodium azide; ammonium chloride in ethanol
T=60°C; 8 h;
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
sodium azide in N,N-dimethyl-formamide
T=60°C; Substitution; 12 h;
参考文献
Nandanan; Phukan, Prodeep; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286
反应条件
1: 86 percent / K3FeCN6; K2CO3; (DHQ)2PHAL / OsO4 / 2-methyl-propan-2-ol; H2O; toluene / 48 h / 20 °C
2: 96 percent / SOCl2 / pyridine / 5 h / 0 °C
3: 92 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 0.5 h / 0 °C
4: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C
5: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C
View Scheme
参考文献
Nandanan; Phukan, Prodeep; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286
反应条件
1: 1.) Et3N, Bu2BOTf / 1.) CH2Cl2, -70 to 20 deg C, 2 h, 2.) -78 to 0 deg C, 1 h
2: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C
3: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C
View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C
2: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C
View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 60 percent / NaN3, NH4Cl / aq. ethanol / Heating
2: 91 percent / pyridine / H2O
3: 35 percent / lipase P / H2O / 68 h / 25 °C / 0.1 M phosphate puffer, pH 7.00
4: NaOMe / methanol
View Scheme
参考文献
Hoenig, H.; Seufer-Wasserthal, P.; Weber, H.
Tetrahedron, 1990 , vol. 46, # 11 p. 3841 - 3850
反应条件
1: 96 percent / SOCl2 / pyridine / 5 h / 0 °C
2: 92 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 0.5 h / 0 °C
3: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C
4: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C
View Scheme
参考文献
Nandanan; Phukan, Prodeep; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286
反应条件
1: 92 percent / NaIO4; RuCl3 / CCl4; acetonitrile; H2O / 0.5 h / 0 °C
2: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C
3: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C
View Scheme
参考文献
Nandanan; Phukan, Prodeep; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286
反应条件
1: 70 percent / MgBr2 / diethyl ether / 12 h / 20 °C
2: 85 percent / NaN3 / dimethylformamide / 12 h / 60 °C
View Scheme
参考文献
Nandanan; Phukan, Prodeep; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999 , vol. 38, # 3 p. 283 - 286
