(6-溴-吡啶-3-基)-乙腈合成路线 （共 7 条）
反应条件
in N,N-dimethyl-formamide T=60°C; 0.5 h;
参考文献
Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1679308 A1, 2006 ;
Location in patent: Page/Page column 35-36 ;
EP 1679308 A1
反应条件
in trans-1,3-dioxane; water T=20°C; 15 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2003/106455 A1, 2003 ;
Location in patent: Page 55-56 ;
WO 03/106455 A1
反应条件
tetrabutylammomium bromide in dichloromethane; water T=20°C; 16 h;
参考文献
AFRAXIS, INC.; CAMPBELL, David; DURÓN, Sergio, G.
Patent: WO2013/43232 A2, 2013 ;
Location in patent: Paragraph 00627 ;
WO 2013/043232 A2
反应条件
in N-methyl-acetamide; water
参考文献
G. D. Searle and Co.
Patent: US5196537 A1, 1993 ;
反应条件
in N,N-dimethyl-formamide T=20°C; 48 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2006/114213 A1, 2006 ;
Location in patent: Page/Page column 31 ;
反应条件
1: 2-bromo-5-methyl-pyridine With N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 2 h; Heating / reflux; 2: potassium cyanide in ethanol; water T=60°C; 2 h;
参考文献
SANKYO COMPANY, LIMITED
Patent: WO2006/109633 A1, 2006 ;
Location in patent: Page/Page column 147-148 ;
反应条件
1: 2-(4-biphenylyl)-5-phenyl-oxazole; N-bromosuccinmide / tetrachloromethane / 16 h / 80 °C / |Inert atmosphere 2: tetrabutylammomium bromide / dichloromethane; water / 16 h / 20 °C View Scheme
参考文献
WO2013/43232 A2, ;
WO 2013/043232 A2
