N-Boc-L-焦谷氨酸乙酯合成路线 （共 4 条）
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
Location in patent: Page/Page column 70-71 ;
US 20080009497 A1
反应条件
1: orthoformic acid triethyl ester; (S)-(-)-2-pyrrolidone-5-carboxylic acid With toluene-4-sulfonic acid in ethanol 4 h; Reflux; 2: di-tert-butyl dicarbonate With 4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; 16 h;
参考文献
EXELIXIS, INC.; IBRAHIM, Mohamed, Abdulkader; JEONG, Joon, Won; JOHNSON, Henry William, Beecroft; KEARNEY, Patrick; LEAHY, James, W.; LEWIS, Gary, L.; NOGUCHI, Robin, Tammie; NUSS, John, M.
Patent: WO2010/45580 A1, 2010 ;
Location in patent: Page/Page column 87-88 ;
WO 2010/045580 A1
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane; di-tert-butyl dicarbonate; ethyl acetate
参考文献
US2002/198255 A1, ;
US 20020198255 A1
反应条件
1: SOCl2 / 0 - 20 °C 2: 3.35 g / DMAP / acetonitrile / 18 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 4, # 14 p. 2696 - 2709
