Boc-D-焦谷氨酸乙酯合成路线

参考文献

Bristol-Myers Squibb Company
Patent: US2008/9497 A1, 2008 ;
Location in patent: Page/Page column 70-71 ;
US 20080009497 A1

24424-99-5二碳酸二叔丁酯+

122-51-0原甲酸三乙酯+

98-79-3L-焦谷氨酸

144978-35-8Boc-D-焦谷氨酸乙酯

参考文献

EXELIXIS, INC.; IBRAHIM, Mohamed, Abdulkader; JEONG, Joon, Won; JOHNSON, Henry William, Beecroft; KEARNEY, Patrick; LEAHY, James, W.; LEWIS, Gary, L.; NOGUCHI, Robin, Tammie; NUSS, John, M.
Patent: WO2010/45580 A1, 2010 ;
Location in patent: Page/Page column 87-88 ;
WO 2010/045580 A1

7149-65-7L-焦谷氨酸乙酯

144978-35-8Boc-D-焦谷氨酸乙酯

参考文献

US2002/198255 A1, ;
US 20020198255 A1

98-79-3L-焦谷氨酸

144978-35-8Boc-D-焦谷氨酸乙酯

参考文献

Organic and Biomolecular Chemistry, , vol. 4, # 14 p. 2696 - 2709

144978-35-8Boc-D-焦谷氨酸乙酯

361440-67-7(1S,3S,5S)-3-(氨基羰基)-2-氮杂双环[3.1.0]己烷-2-甲酸叔丁酯

参考文献

Dong, Jizhe; Gong, Yanchun; Liu, Jun; Chen, Xiangfeng; Wen, Xiaoan; Sun, Hongbin
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 4 p. 1383 - 1393

144978-35-8Boc-D-焦谷氨酸乙酯

334769-80-1(2S,5S)-N-Boc-5-甲基吡咯烷-2-甲酸

参考文献

GILEAD SCIENCES, INC.; BACON, Elizabeth, M.; COTTELL, Jeromy, J.; KATANA, Ashley, Anne; KATO, Darryl; KRYGOWSKI, Evan, S.; LINK, John, O.; TAYLOR, James; TRAN, Chinh Viet; TREJO MARTIN, Teresa, Alejandra; YANG, Zheng-Yu; ZIPFEL, Sheila
Patent: WO2013/75029 A1, 2013 ;

144978-35-8Boc-D-焦谷氨酸乙酯

214193-13-2

参考文献

Hanessian, Stephen; Reinhold, Ulrich; Saulnier, Michel; Claridge, Stephen
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 16 p. 2123 - 2128

144978-35-8Boc-D-焦谷氨酸乙酯

214193-11-0

参考文献

Hanessian, Stephen; Reinhold, Ulrich; Saulnier, Michel; Claridge, Stephen
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 16 p. 2123 - 2128

144978-35-8Boc-D-焦谷氨酸乙酯

194594-24-65-甲氧基吡咯烷-1,2-二羧酸-(2S)-1-叔丁基-2-乙酯

参考文献

Pichon, Marianne; Figadere, Bruno; Cave, Andre
Tetrahedron Letters, 1996 , vol. 37, # 44 p. 7963 - 7966

67-56-1甲醇+

144978-35-8Boc-D-焦谷氨酸乙酯

194594-24-65-甲氧基吡咯烷-1,2-二羧酸-(2S)-1-叔丁基-2-乙酯

参考文献

Zhang, Xiaojun; Schmitt, Aaron C.; Jiang, Wen; Wasserman, Zelda; Decicco, Carl P.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1157 - 1160