2-羟基-5-甲基苯乙酮合成路线 （共 181 条）
反应条件
potassium carbonate in acetone 12 h; Reflux;
参考文献
Wang, Xiao-Bing; Yang, Lei; Kong, Ling-Yi; Liu, Wei; Guo, Qing-Long
Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1833 - 1849,17
反应条件
sodium Acylation; Heating;
参考文献
Ghosh, Chandra Kanta; Bhattacharyya, Samita; Ghosh, Chandreyi; Patra, Amarendra
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 3005 - 3013
反应条件
potassium carbonate in N,N-dimethyl-formamide
18 h; Ambient temperature;
参考文献
Buckle, Derek, R.; Rockell, Caroline J. M.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2443 - 2446
参考文献
Letcher, Roy M.; Ng, Kai-Wing
Journal of Chemical Research, Miniprint, 1989 , # 7 p. 1480 - 1500
反应条件
potassium hydroxide
T=60°C; 16 h;
参考文献
Subbanwad; Vibhute; Shingare
Journal of the Indian Chemical Society, 1991 , vol. 68, # 10 p. 570 - 571
反应条件
1: NaBr; oxone / acetone; H2O
2: K2CO3 / acetone / 45 °C
3: 100 percent / MCPA; p-TsOH / CHCl3 / 3 h / 50 °C
4: Na / methanol / 20 °C
5: CuBr / dimethylformamide; H2O / 130 °C
View Scheme
参考文献
Bovicelli, Paolo; Antonioletti, Roberto; Barontini, Maurizio; Borioni, Giorgio; Bernini, Roberta; Mincione, Enrico
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1255 - 1257
反应条件
1: Na / Heating
2: HCl / aq. methanol / 0.5 h / Heating
View Scheme
参考文献
Ghosh, Chandra Kanta; Bhattacharyya, Samita; Ghosh, Chandreyi; Patra, Amarendra
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 3005 - 3013
反应条件
1: 80 percent / K2CO3 / acetone / 6 h / 70 °C / Heating
2: 39 percent / KOH / dioxane / 6 h / 60 °C
View Scheme
参考文献
Suzuki, Tsuneo; Tanemura, Kiyoshi; Horaguchi, Takaaki; Shimimizu, Takahachi; Sakakibara, Tohru
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 423 - 429
反应条件
1: 2 h / 80 - 90 °C
2: 65 percent / NH2OH*HCl / ethanol / 0.5 h / Heating
3: 75 percent / Et3N / dimethylformamide / 8 h / Heating
View Scheme
参考文献
Ghosh, Tarun; Saha, Satyajit; Bandyopadhyay, Chandrakanta
Synthesis, 2005 , # 11 art. no. T14704SS, p. 1845 - 1849
反应条件
1: 56 percent / pyridine / 0.33 h / 50 °C
2: 53 percent / pyridine; KOH / 0.25 h / 50 °C
3: 83 percent / glacial acetic acid / 48 h / Heating
View Scheme
参考文献
Dekermendjian, Kim; Kahnberg, Pia; Witt, Michael-Robin; Sterner, Olov; Nielsen, Mogens; Liljefors, Tommy
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4343 - 4350
