2-羟基-5-甲基苯乙酮合成路线 （共 181 条）
反应条件
sulfur in water
T=100°C; 8 h;
参考文献
Kuliev, A. B.; Anave, P. A. L.; Kuliev, F. A.; Mamedova, Sh. E.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 1493 - 1494
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 8 p. 1709 - 1711
反应条件
1.1: 63 percent / glacial acetic acid; nitric acid / 15 - 20 °C
2.1: sodium ethoxide / ethanol / 0.5 h
2.2: 86 percent / ethanol / 2 h / Heating
View Scheme
参考文献
Anderluh, Marko; Marc, Gasper; Dolenc, Marija Sollner
Synthetic Communications, 2005 , vol. 35, # 11 p. 1461 - 1470
反应条件
1: 50percent NaH/mineral oil / tetrahydrofuran / Ambient temperature
2: 50percent NaH/mineral oil, 18 crown 6 / dioxane / 3 h / 65 °C
3: Redex CF resin
View Scheme
参考文献
Humbert; Dagnaux; Cohen; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 1 p. 67 - 78
反应条件
potassium hydroxide in ethanol
T=20°C; 24 h;
参考文献
Popat; Nimavat; Kachhadia; Joshi
Journal of the Indian Chemical Society, 2003 , vol. 80, # 7 p. 707 - 708
反应条件
hydrogenchloride
1) 70 deg C to 80 deg C, 7 h, 2) 20 deg C, 12 h;
参考文献
Aitken, R. Alan; Bibby, Michael C.; Double, John A.; Phillips, Roger M.; Sharma, Shiv Kumar
Archiv der Pharmazie, 1996 , vol. 329, # 11 p. 489 - 497
反应条件
hydrogenchloride; acetic acid
T=0 - 70°C; 10 h;
参考文献
Goswami, Jonali; Borthakur, Naleen; Goswami, Amrit
Journal of Chemical Research - Part S, 2003 , # 4 p. 200 - 203
反应条件
1: 78 percent / conc. HCl / 1) 70 deg C to 80 deg C, 7 h, 2) 20 deg C, 12 h
2: 82 percent / conc. HCl, Fe / 4.5 h / Heating
3: 80 percent / NaH / tetrahydrofuran / Heating
4: 68 percent / 48percent HBr / acetic acid / 4 h / 80 °C
5: ethanol; H2O / 12 h / Heating
6: conc. H2SO4 / aq. acetic acid / 5 h / Heating
View Scheme
参考文献
Aitken, R. Alan; Bibby, Michael C.; Double, John A.; Phillips, Roger M.; Sharma, Shiv Kumar
Archiv der Pharmazie, 1996 , vol. 329, # 11 p. 489 - 497
反应条件
1: K2CO3 / dimethylformamide / 90 °C
2: aq. NaOH / tetrahydrofuran
View Scheme
参考文献
Suzuki, Tsuneo; Tanemura, Kiyoshi; Horaguchi, Takaaki; Shimimizu, Takahachi; Sakakibara, Tohru
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 423 - 429
反应条件
pyridine
T=50°C; Schotten-Baumann reaction; 0.5 h;
参考文献
Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
反应条件
pyridine; trichlorophosphate
1) below 5 deg C, 2 h, 2) overnight (ice chest);
参考文献
Mazumdar; Karmakar; Rangachari; Banerjee; Banerji
Journal of the Indian Chemical Society, 1990 , vol. 67, # 11 p. 911 - 913
