2-羟基-5-甲基苯乙酮合成路线 （共 181 条）
反应条件
1: potassium carbonate / acetone / 12 h / |Reflux
2: sodium acetate; acetic acid / 12 h / |Reflux
View Scheme
参考文献
Wang, Xiao-Bing; Yang, Lei; Kong, Ling-Yi; Liu, Wei; Guo, Qing-Long
Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1833 - 1849,17
反应条件
in anhydrous xylene
2 h; Reflux;
参考文献
Balbi, Alessandro; Anzaldi, Maria; MacCi, Chiara; Aiello, Cinzia; Mazzei, Mauro; Gangemi, Rosaria; Castagnola, Patrizio; Miele, Mariangela; Rosano, Camillo; Viale, Maurizio
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5293 - 5309
反应条件
T=150°C; 0.0166667 h; Microwave irradiationSealed tube;
参考文献
Bornadiego, Ana; Diaz, Jesus; Marcos, Carlos F.
Advanced Synthesis and Catalysis, 2014 , vol. 356, # 4 p. 718 - 722
反应条件
1: 60 percent / ethanol / 0.17 h / Heating
2: 31 percent / SOCl2 / 0.17 h / Ambient temperature
View Scheme
参考文献
Loewe, Werner; Kennemann, Angela
Archiv der Pharmazie (Weinheim, Germany), 1985 , vol. 318, # 3 p. 239 - 243
反应条件
1.1: LHMDS / tetrahydrofuran / 2.5 h / -78 - -20 °C
1.2: tetrahydrofuran / 3 h / -78 - 20 °C
1.3: 61 percent / AcOH; H2SO4 / tetrahydrofuran / 0.08 h / 120 °C
2.1: 57 percent / NaOtBu / Pd2(dba)3; BINAP / toluene / 1 h / 80 °C / microwave irradiation
View Scheme
参考文献
Fitzmaurice, Richard J.; Etheridge, Zac C.; Jumel, Emelie; Woolfson, Derek N.; Caddick, Stephen
Chemical Communications, 2006 , # 46 p. 4814 - 4816
反应条件
sodium hydroxide; ethanol
unter Luftzutritt;
参考文献
Marathe
Journal of the University of Poona, Science and Technology, 1958 , # 14 p. 63,66
反应条件
triethylamine in benzene
T=40 - 50°C; 2 h;
参考文献
Popkova, T. N.; Kukhareva, T. S.; Bekker, A. R.; Nifant'ev, E. E.
J. Gen. Chem. USSR (Engl. Transl.), 1986 , vol. 56, # 8 p. 1813 - 1818,1604 - 1608
反应条件
in pyridine
T=70°C; 0.25 h;
参考文献
Lichtenstein, N.; Mueller, D.
Organic Mass Spectrometry, 1985 , vol. 20, # 6 p. 432 - 433
反应条件
1: 91 percent / pyridine / 0.5 h / 50 °C
2: 85 percent / pyridine; KOH / 1.5 h / 50 °C
3: 85 percent / conc. H2SO4 / acetic acid / 2 h / 80 °C
4: 92 percent / BBr3 / CH2Cl2 / 18 h / -78 - 20 °C
View Scheme
参考文献
Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
反应条件
1: potassium carbonate / acetone / 12 h / |Reflux
2: sodium acetate; acetic acid / 12 h / |Reflux
3: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 12 h / |Reflux
View Scheme
参考文献
Roy, Somnath Singha; Chakraborty, Pramita; Bhattacharya, Sudin
European Journal of Medicinal Chemistry, 2014 , vol. 73, p. 195 - 209
