2-羟基-5-甲基苯乙酮合成路线 （共 181 条）
参考文献
Dave, L. D.; Amma E., Komala
Journal of the Indian Chemical Society, 1984 , vol. 61, # 2 p. 164 - 165
参考文献
Hiremath, S. N.; Kulkarni, V. H.
Acta Chimica Academiae Scientiarum Hungaricae, 1982 , vol. 111, # 2 p. 225 - 232
参考文献
Hiremath, S. N.; Kulkarni, V. H.
Acta Chimica Academiae Scientiarum Hungaricae, 1982 , vol. 111, # 2 p. 225 - 232
参考文献
Joshi, U. K.; Kelkar, R. M.; Paradkar, M. V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 11 p. 1151 - 1152
反应条件
1: 75 percent / pyrrolidine / toluene / 1.) RT, 1 h, 2.) reflux, 8 h
2: 92 percent / thallium(III) p-tosylate / acetonitrile / 1 h / Heating
3: 75 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / dioxane / 18 h / Heating
View Scheme
参考文献
Singh, Om V.; George, Varughese; Kapil, Randhir S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 10 p. 856 - 864
反应条件
copper(ll) bromide in chloroform; ethyl acetate
T=100°C; 18 h;
参考文献
SMITHKLINE BEECHAM CORPORATION; BOUILLOT, Anne Marie Jeanne; DODIC, Nerina; GELLIBERT, Francoise Jeanne; MIRGUET, Olivier
Patent: WO2010/15652 A2, 2010 ;
Location in patent: Page/Page column 31 ;
WO 2010/015652 A2
反应条件
1: pyridine / 1 h / 0 °C
2: potassium tert-butylate / tetrahydrofuran / 0.5 h / 50 °C
3: NH2NH2•xH2O; acetic acid / tetrahydrofuran / 16 h / 65 °C
View Scheme
参考文献
Alkhouri, Bashar; Denning, Robert A.; Chiaw, Patrick Kim; Eckford, Paul D.W.; Yu, Wilson; Li, Canhui; Bogojeski, Jovanka J.; Bear, Christine E.; Viirre, Russell D.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8693 - 8701
反应条件
hydrogenchloride; zinc in ethanol
54 h; Heating;
参考文献
Thakar; Joshi
Journal of the Indian Chemical Society, 1982 , vol. 59, # 1 p. 77 - 79
反应条件
T=85 - 115°C; unter Druck.Hydrogenation;
参考文献
Ungnade; McLaren
Journal of the American Chemical Society, 1944 , vol. 66, p. 118,119
参考文献
Hill; Graf
Journal of the American Chemical Society, 1915 , vol. 37, p. 1845
