2-羟基-5-甲基苯乙酮合成路线 （共 181 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 365, p. 315,338
反应条件
1: 2 h / 80 - 90 °C 2: 65 percent / NH2OH*HCl / ethanol / 0.5 h / Heating View Scheme
参考文献
Ghosh, Tarun; Saha, Satyajit; Bandyopadhyay, Chandrakanta
Synthesis, 2005 , # 11 art. no. T14704SS, p. 1845 - 1849
反应条件
1: 56 percent / pyridine / 0.33 h / 50 °C 2: 53 percent / pyridine; KOH / 0.25 h / 50 °C View Scheme
参考文献
Alkhouri, Bashar; Denning, Robert A.; Chiaw, Patrick Kim; Eckford, Paul D.W.; Yu, Wilson; Li, Canhui; Bogojeski, Jovanka J.; Bear, Christine E.; Viirre, Russell D.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 24 p. 8693 - 8701
反应条件
potassium carbonate in acetone 12 h; Reflux;
参考文献
Wang, Xiao-Bing; Yang, Lei; Kong, Ling-Yi; Liu, Wei; Guo, Qing-Long
Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1833 - 1849,17
反应条件
sodium hydroxide T=50°C;
参考文献
v. Auwers; Anschuetz
Chemische Berichte, 1921 , vol. 54, p. 1553
反应条件
1: sodium hydride 2: trichlorophosphate / 2.25 h / -10 - 60 °C View Scheme
参考文献
Kumar, J. Ashok; Saidachary; Mallesham; Sridhar; Jain, Nishant; Kalivendi, Shashi Vardhan; Rao, V. Jayathirtha; Raju, B. China
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 389 - 402
反应条件
1: NaBr; oxone / acetone; H2O 2: K2CO3 / acetone / 45 °C 3: 100 percent / MCPA; p-TsOH / CHCl3 / 3 h / 50 °C 4: Na / methanol / 20 °C 5: CuBr / dimethylformamide; H2O / 130 °C 6: O2 / Co(salen) View Scheme
参考文献
Bovicelli, Paolo; Antonioletti, Roberto; Barontini, Maurizio; Borioni, Giorgio; Bernini, Roberta; Mincione, Enrico
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1255 - 1257
反应条件
1: sodium; diethyl ether 2: sulfuric acid; ethanol View Scheme
参考文献
Schoenberg; Sina
Journal of the American Chemical Society, 1950 , vol. 72, p. 3396,3398
反应条件
1: N,N-dimethyl-formamide With bis(trichloromethyl) carbonate in 1,2-dichloro-ethane T=0 - 20°C; 2: 1-(2-hydroxy-5-methylphenyl)ethanone in 1,2-dichloro-ethane T=0 - 20°C; 4.5 h; Further stages.;
参考文献
Su; Li; Zhao
Organic Preparations and Procedures International, 2007 , vol. 39, # 5 p. 495 - 502
反应条件
1: Na / Heating 2: HCl / aq. methanol / 0.5 h / Heating 3: 48 percent / pyridine / 8 h / Heating 4: dimethylformamide / 8 h / Heating View Scheme
参考文献
Ghosh, Chandra Kanta; Bhattacharyya, Samita; Ghosh, Chandreyi; Patra, Amarendra
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 3005 - 3013
