2-羟基-5-氯苯乙酮合成路线 （共 106 条）
反应条件
pyrrolidine in toluene
1) 24 h, 2) heating;
参考文献
Kabbe, Hans-Joachim; Widdig, Arno
Angewandte Chemie, 1982 , vol. 94, # 4 p. 254 - 262
反应条件
potassium hydroxide in ethanol
T=20°C;
参考文献
Ghotekar; Mandhane; Joshi; Bhagat; Gill
Indian Journal of Heterocyclic Chemistry, 2010 , vol. 19, # 4 p. 341 - 344
反应条件
sodium methylate in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Bolos; Loscertales; Nieto; Sacristan; Ortiz
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1203 - 1208
反应条件
piperidine
1 h; Ambient temperature;
参考文献
Upadhyay, Kuldip; Bavishi, Abhay; Thakrar, Shailesh; Radadiya, Ashish; Vala, Hardevsinh; Parekh, Shrey; Bhavsar, Dhairya; Savant, Mahesh; Parmar, Manisha; Adlakha, Priti; Shah, Anamik
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2547 - 2549
反应条件
1.1: Ba(OH)2 / ethanol / 0.33 h / Reflux
1.2: Cooling with ice
2.1: benzene / 8 h / Irradiation
View Scheme
参考文献
Kamboj, Ramesh C.; Berar, Surinder; Berar, Urmila; Gupta, Satish C.
Journal of the Indian Chemical Society, 2011 , vol. 88, # 6 p. 879 - 885
反应条件
pyridine; trichlorophosphate
T=0 - 5°C;
参考文献
Mazumdar; Karmakar; Tiwari; Banerjee; Banerji
Journal of the Indian Chemical Society, 1990 , vol. 67, # 10 p. 845 - 847
反应条件
1: 87 percent / POCl3, pyridine / 0 - 5 °C
2: 1) KOH, pyridine / 2) conc. HCl / 1) 60 deg C, 2h, 2) glacial acetic acid, reflux, 1h
View Scheme
参考文献
Mazumdar; Karmakar; Tiwari; Banerjee; Banerji
Journal of the Indian Chemical Society, 1990 , vol. 67, # 10 p. 845 - 847
反应条件
potassium carbonate in pyridine
T=120°C; 3 h; Heating / reflux;
参考文献
Li, Gui-Rong; Lau, Chu-Pak; Qin, Guo-Wei; Wang, Hong-Bing
Patent: US2008/214493 A1, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
1: potassium hydroxide / ethanol; water / 20 °C
2: iodine / dimethyl sulfoxide / |Reflux
View Scheme
参考文献
Sawant; Gill; Nirwan
Indian Journal of Heterocyclic Chemistry, 2012 , vol. 21, # 4 p. 297 - 300
反应条件
1.1: 0.5 h / -10 °C
1.2: -10 - 20 °C
2.1: sodium chlorite; aminosulfonic acid / water; dichloromethane / 0.5 h / 0 °C
View Scheme
参考文献
Helguera, Aliuska Morales; Perez-Garrido, Alfonso; Gaspar, Alexandra; Reis, Joana; Cagide, Fernando; Vina, Dolores; Cordeiro, M.Natalia D.S.; Borges, Fernanda
European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 75 - 90
