2-羟基-5-氯苯乙酮合成路线 （共 106 条）
参考文献
Chondhekar, T. K.; Khanolkar, D. D.
Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical & Analytical, 1986 , vol. 25, # 9 p. 868 - 870
反应条件
sodium ethanolate 8 h; Heating;
参考文献
Nizamuddin; Giri; Mishra
Acta Chimica Academiae Scientiarum Hungaricae, 1982 , vol. 110, # 2 p. 117 - 122
反应条件
1: 89 percent / pyridine / 70 °C 2: 53 percent / t-BuOK / tetrahydrofuran / 20 °C View Scheme
参考文献
Marder, Mariel; Zinczuk, Juan; Colombo, Maria I.; Wasowski, Cristina; Viola, Haydee; Wolfman, Claudia; Medina, Jorge H.; Ruveda, Edmundo A.; Paladini, Alejandro C.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 2003 - 2008
反应条件
1: N,N-dimethyl-formamide With bis(trichloromethyl) carbonate in 1,2-dichloro-ethane T=0 - 20°C; 2: 1-(5-chloro-2-hydroxyphenyl)-1-ethanone in 1,2-dichloro-ethane T=0 - 20°C; 4.5 h; Further stages.;
参考文献
Su; Li; Zhao
Organic Preparations and Procedures International, 2007 , vol. 39, # 5 p. 495 - 502
反应条件
phenyltrimethylammonium tribromide in tetrahydrofuran T=20°C; 8 h;
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1514544 A1, 2005 ;
Location in patent: Page/Page column 170 ;
反应条件
in dichloromethane; chloroform; ethyl acetate
参考文献
Tokizawa, Minoru; Takeda, Sunao; Kaneko, Yasushi; Kusano, Koji; Eto, Hiromichi; Tachinaba, Koichi; Sato, Susumu; Taniyama, Tadayoshi
Patent: US2003/176482 A1, 2003 ;
反应条件
1: 22 percent / conc. HCl / propan-2-ol / 5 h / Heating 2: 38 percent / 0.02 M aq. KOH / H2O / 0.25 h / 35 °C View Scheme
参考文献
Cox, Brian; Waigh, Roger D.
Synthesis, 1989 , # 9 p. 709 - 710
反应条件
boron trifluoride diethyl etherate; trichlorophosphate T=50 - 60°C; Vilmeier reaction;
参考文献
Prakash, Om; Kumar, Ravi; Sharma, Deepak; Bhardwaj, Vikas
Journal of the Indian Chemical Society, 2004 , vol. 81, # 10 p. 888 - 890
反应条件
1: anhydrous xylene / 2 h / Reflux 2: ethanol / 2 h / 60 °C View Scheme
参考文献
Balbi, Alessandro; Anzaldi, Maria; MacCi, Chiara; Aiello, Cinzia; Mazzei, Mauro; Gangemi, Rosaria; Castagnola, Patrizio; Miele, Mariangela; Rosano, Camillo; Viale, Maurizio
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5293 - 5309
反应条件
sodium acetate; chlorine; acetic acid T=20°C; 0.5 h;
参考文献
Rajput, P. R.; Gajbhiye, A. V.; Bhade, M. W.
Asian Journal of Chemistry, 2012 , vol. 24, # 12 p. 5699 - 5701,3
Title/Abstract Full Text Show Details
Rajput; Gajbhiye; Bhade
Asian Journal of Chemistry, 2012 , vol. 24, # 12 p. 5699 - 5701
