2-羟基-5-氯苯乙酮合成路线 （共 106 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19184 A1, 2005 ;
Location in patent: Page/Page column 74 ;
WO 2005/019184 A1
反应条件
potassium carbonate; methyl iodide in acetonitrile T=85°C; 18 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19184 A1, 2005 ;
Location in patent: Page/Page column 43-44 ;
WO 2005/019184 A1
参考文献
Horton,W.J.; Robertson,D.E.
Journal of Organic Chemistry, 1960 , vol. 25, p. 1016 - 1020
反应条件
1: 2 h / 100 °C 2: bromine / chloroform / 0.08 h / 0 - 23 °C View Scheme
参考文献
Bryan, Marian C.; Biswas, Kaustav; Peterkin, Tanya A.N.; Rzasa, Robert M.; Arik, Leyla; Lehto, Sonya G.; Sun, Hong; Hsieh, Feng-Yin; Xu, Cen; Fremeau, Robert T.; Allen, Jennifer R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 619 - 622
反应条件
1: 95 percent / K2CO3 / acetone / 5 h / Heating 2: 88 percent / NaH / Heating 3: 1.) NaH / 1) benzene, 1 h, room temperature; 2) benzene, 5 - 10 deg C, 1 h 4: 1.) cyclohexene, 2.) conc. hydrochloric acid / 1.) Pd/C / 1) EtOH, reflux; 2) MeOH, reflux View Scheme
参考文献
Witiak, Donald T.; Kim, Sung K.; Tehim, Ashok K.; Sternitzke, Kent D.; McCreery, Richard L.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1437 - 1445
反应条件
palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide T=120°C; P=3750.38 Torr; 16 h; Autoclave;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2012 , vol. 18, # 40 p. 12595 - 12598
反应条件
1: pyridine 2: KOH / pyridine 3: H2SO4 / acetic acid View Scheme
参考文献
Das, Jhantu; Ghosh, Somnath
Tetrahedron Letters, 2011 , vol. 52, # 52 p. 7189 - 7194
反应条件
1: sodium hydroxide / ethanol / 20 °C 2: copper(l) iodide; oxygen / 40 h / 50 °C / 760.05 Torr / Ionic liquid View Scheme
参考文献
Du, Zhiyun; Ng, Huifen; Zhang, Kun; Zeng, Huaqiang; Wang, Jian
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6930 - 6933
反应条件
anhydrous sodium benzoate T=180 - 210°C;
参考文献
Wittig
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 179
反应条件
1.5mol Pd/C; hydrogen; sodium hydrogencarbonate in methanol T=20°C; 0.833333 h; regioselective reaction;
参考文献
Ramanathan, Ahalya; Jimenez, Leslie S.
Synthesis, 2010 , # 2 art. no. M04609SS, p. 217 - 220
