2-羟基-5-氯苯乙酮合成路线 （共 106 条）
反应条件
1: acetic acid / Heating 2: 66.9 percent / polypohophoric acid / 1 h / 120 °C View Scheme
参考文献
Xu, Xiu-Hua; Taniguchi, Misaki; Azuma, Ayaka; Liu, Guo Kai; Tokunaga, Etsuko; Shibata, Norio
Organic Letters, 2013 , vol. 15, # 3 p. 686 - 689
反应条件
sodium hydroxide in methanol; water T=20°C;
参考文献
Aryapour, Hassan; Riazi, Gholam Hossein; Foroumadi, Alireza; Ahmadian, Shahin; Shafiee, Abbas; Karima, Oveis; Mahdavi, Majid; Emami, Saeed; Sorkhi, Maedeh; Khodadady, Sirus
Medicinal Chemistry Research, 2011 , vol. 20, # 4 p. 503 - 510
反应条件
1: NaOH / ethanol 2: NaOAc / ethanol View Scheme
参考文献
Yang, Guangfu; Jiang, Xiaohua; Yang, Huazheng
Pest Management Science, 2002 , vol. 58, # 10 p. 1063 - 1067
反应条件
sodium hydroxide in ethanol T=0 - 5°C;
参考文献
Basawaraj, Raga; Alvi, Shah Nadeemuddin; Chillargi, Neelavati; Gahininath, Wadikar; Zaheeruddin
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 21, # 2 p. 147 - 150
反应条件
1: 1-(5-chloro-2-hydroxyphenyl)-1-ethanone With sodium hydride in toluene; mineral oil 2: carbonic acid diethyl ester in toluene; mineral oil Reflux; 3: With hydrogenchloride in water
参考文献
Zhao, Pei-Liang; Wang, Le; Zhu, Xiao-Lei; Huang, Xiaoqin; Zhan, Chang-Guo; Wu, Jia-Wei; Yang, Guang-Fu
Journal of the American Chemical Society, 2010 , vol. 132, # 1 p. 185 - 194
反应条件
1: 48 percent / PhN(Me)MgBr / diethyl ether / 3 h / 20 °C 2: 77 percent / conc. HCl / 24 h / 20 °C 3: 45 percent / KOH / methanol / 0.5 h / Heating View Scheme
参考文献
Sosnovskikh; Kutsenko; Ovsyannikov
Russian Chemical Bulletin, 2000 , vol. 49, # 3 p. 478 - 481
反应条件
sodium hydroxide in ethanol T=0 - 5°C;
参考文献
Basawaraj, Raga; Alvi, Shah Nadeemuddin; Chillargi, Neelavati; Gahininath, Wadikar; Zaheeruddin
Indian Journal of Heterocyclic Chemistry, 2011 , vol. 21, # 2 p. 147 - 150
反应条件
sodium hydroxide in ethanol
参考文献
Yang, Guangfu; Jiang, Xiaohua; Yang, Huazheng
Pest Management Science, 2002 , vol. 58, # 10 p. 1063 - 1067
反应条件
1: potassium hydroxide / ethanol; water / 20 °C
2: iodine / dimethyl sulfoxide / |Reflux
View Scheme
参考文献
Sawant; Gill; Nirwan
Indian Journal of Heterocyclic Chemistry, 2012 , vol. 21, # 4 p. 297 - 300
反应条件
1: 80 percent / pyrrolidine / toluene / 1.) RT, 1 h, 2.) reflux, 8 h
2: 94 percent / thallium(III) p-tosylate / acetonitrile / 1 h / Heating
3: 80 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / dioxane / 18 h / Heating
View Scheme
参考文献
Singh, Om V.; George, Varughese; Kapil, Randhir S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 10 p. 856 - 864
