2-羟基-5-氯苯乙酮合成路线 （共 106 条）
反应条件
1.1: sodium hydride / tetrahydrofuran / 72 h / 0 - 20 °C / |Inert atmosphere
1.2: |Inert atmosphere
2.1: palladium diacetate; 1,10-phenanthroline / acetonitrile / 20 h / 110 °C / 1034.32 Torr / |Autoclave
View Scheme
参考文献
Ferguson, Jamie; Zeng, Fanlong; Alper, Howard
Organic Letters, 2012 , vol. 14, # 21 p. 5602 - 5605,4
反应条件
sodium acetate
T=160 - 170°C;
参考文献
Wittig
Chemische Berichte, 1924 , vol. 57, p. 92
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 157 Anm. 2, 177
反应条件
sodium acetate
T=160 - 170°C;
参考文献
Wittig
Chemische Berichte, 1924 , vol. 57, p. 92
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 157 Anm. 2, 177
参考文献
Wittig
Chemische Berichte, 1924 , vol. 57, p. 92
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 157 Anm. 2, 177
反应条件
sodium hydroxide in ethanol; water
参考文献
LG Chemical, Ltd.
Patent: US6500846 B1, 2002 ;
反应条件
1: 1-(5-chloro-2-hydroxyphenyl)-1-ethanone With sodium hydroxide in ethanol; water
T=0°C; 0.5 h;
2: piperonal in ethanol; water
T=0 - 20°C; 12 h;
参考文献
Wang, Fang-Wu; Wang, Sheng-Qing; Zhao, Bao-Xiang; Miao, Jun-Ying
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 19 p. 3062 - 3070
反应条件
sodium acetate
T=160 - 170°C;
参考文献
Wittig
Chemische Berichte, 1924 , vol. 57, p. 92
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 157 Anm. 2, 177
反应条件
1: sodium
2: concentrated sulfuric acid
View Scheme
参考文献
Wittig
Chemische Berichte, 1924 , vol. 57, p. 92
Justus Liebigs Annalen der Chemie, 1926 , vol. 446, p. 157 Anm. 2, 177
反应条件
1: trichlorophosphate; pyridine / 0 °C / |Sonication
2: potassium hydroxide; pyridine / |Sonication
View Scheme
参考文献
Chate, Asha V.; Ghotekar, Dattatraya S.; Bhagat, Sunil S.; Gill, Charansingh H.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 149 - 154
反应条件
pyridine; trichlorophosphate
T=0°C; Sonication;
参考文献
Chate, Asha V.; Ghotekar, Dattatraya S.; Bhagat, Sunil S.; Gill, Charansingh H.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 149 - 154
