2-羟基-5-氯苯乙酮合成路线 （共 106 条）
反应条件
pyridine; hydroxylamine hydrochloride in methanol
T=20°C;
参考文献
Kociolek, Martin George; Casbohm, Jerry S.
Journal of Physical Organic Chemistry, 2013 , vol. 26, # 10 p. 863 - 867
反应条件
nitric acid in acetic acid
T=100°C; 0.5 h;
参考文献
Benedikt, George M.; Traynor, Lee
Tetrahedron Letters, 1987 , vol. 28, # 7 p. 763 - 766
反应条件
1: sodium hydride / toluene / 110 °C
2: ammonium acetate / toluene / 130 °C
View Scheme
参考文献
Peng, Shiyong; Wang, Lei; Huang, Jiayao; Sun, Shaofa; Guo, Haibing; Wang, Jian
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 13 p. 2550 - 2557
反应条件
trichlorophosphate in pyridine
T=50°C; 3 h;
参考文献
Thool; Ghiya
Journal of the Indian Chemical Society, 1988 , vol. 65, # 7 p. 522 - 524
反应条件
tert.-butylhydroperoxide; Cu(OAc)2*2H2O in decane
T=120°C; 5.5 h; chemoselective reaction;
参考文献
Rout, Saroj Kumar; Guin, Srimanta; Banerjee, Arghya; Khatun, Nilufa; Gogoi, Anupal; Patel, Bhisma K.
Organic Letters, 2013 , vol. 15, # 16 p. 4106 - 4109
参考文献
Letcher, Roy M.
Journal of Chemical Research, Miniprint, 1989 , # 12 p. 2901 - 2929
反应条件
1: phosphorous oxychloride / pyridine / 3 h / 50 °C
2: KOH / pyridine / 2 h
View Scheme
参考文献
Thool; Ghiya
Journal of the Indian Chemical Society, 1988 , vol. 65, # 7 p. 522 - 524
反应条件
1: pyrrolidine / acetonitrile / 8 h / 45 °C
2: p-TsOH*H2O / toluene / 22 h / 100 °C
View Scheme
参考文献
Gerlach; Brendel; Lang; Paulus; Weidmann; Brueggemann; Busch; Suessbrich; Bleich; Greger
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3831 - 3837
反应条件
pyrrolidine in methanol
T=25°C;
参考文献
Sebille, Sophie; De Tullio, Pascal; Becker, Benedicte; Antoine, Marie-Helene; Boverie, Stephane; Pirotte, Bernard; Lebrun, Philippe
Journal of Medicinal Chemistry, 2005 , vol. 48, # 2 p. 614 - 621
参考文献
Eisai Co., Ltd.
Patent: US4540704 A1, 1985 ;
