2′-羟基-5′-溴苯乙酮合成路线 （共 81 条）
反应条件
trichlorophosphate in water; N,N-dimethyl-formamide
参考文献
Sandoz Ltd.
Patent: US4320133 A1, 1982 ;
反应条件
1: 96 percent / pyridine / 70 °C 2: 84 percent / t-BuOK / tetrahydrofuran / 20 °C View Scheme
参考文献
Marder, Mariel; Zinczuk, Juan; Colombo, Maria I.; Wasowski, Cristina; Viola, Haydee; Wolfman, Claudia; Medina, Jorge H.; Ruveda, Edmundo A.; Paladini, Alejandro C.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 2003 - 2008
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene T=80°C; Baker-Venkataraman rearrangement; 16 h;
参考文献
Abdel Ghani, Sherif B.; Weaver, Louise; Zidan, Zidan H.; Ali, Hussein M.; Keevil, C. William; Brown, Richard C.D.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 518 - 522
反应条件
sodium hydride in toluene T=100°C; 4.5 h; Cooling with ice;
参考文献
Zhang, Wenjuan; Li, Zhi; Zhou, Meng; Wu, Feng; Hou, Xueyan; Luo, Hao; Liu, Hao; Han, Xuan; Yan, Guoyi; Ding, Zhenyu; Li, Rui
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 799 - 807
反应条件
1: 88.7 percent / pyridine / 0.5 h / 80 °C 2: 74.3 percent / KOH; pyridine / 1 h / 60 °C 3: 89.5 percent / sulfuric acid / 0.33 h / 20 °C View Scheme
参考文献
Goeker, Hakan; Boykin, David W.; Yildiz, Sulhiye
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1707 - 1714
反应条件
1: pyridine / 0 - 20 °C 2: KOH / pyridine / 40 °C 3: sulfuric acid / acetic acid / Heating View Scheme
参考文献
Springsteel, Mark F.; Galietta, Luis J. V.; Ma, Tonghui; By, Kolbot; Berger, Gideon O.; Yang, Hong; Dicus, Christopher W.; Choung, Wonken; Quan, Chao; Shelat, Anang A.; Guy, R. Kiplin; Verkman; Kurth, Mark J.; Nantz, Michael H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4113 - 4120
反应条件
1: 96.5 percent / pyridine / 0.58 h 2: 85.2 percent / KOH; pyridine / 0.25 h / 50 °C 3: 79.4 percent / H2SO4; AcOH / 1 h / Heating 4: 13.1 percent / BBr3 / CH2Cl2 / 6 h / 20 °C View Scheme
参考文献
Ono, Masahiro; Yoshida, Naoko; Ishibashi, Kenichi; Haratake, Mamoru; Arano, Yasushi; Mori, Hiroshi; Nakayama, Morio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7253 - 7260
反应条件
water; iodine; iodic acid 0.5 h; neat (no solvent); regioselective reaction;
参考文献
Vibhute, Archana; Mokle, Shyam; Karamunge, Khushal; Gurav, Vasant; Vibhute, Yeshwant
Chinese Chemical Letters, 2010 , vol. 21, # 8 p. 914 - 918
反应条件
sodium hydroxide; hydrazine in 1,2-bis-(2-hydroxyethoxy)-ethane T=170°C; 24 h;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 26 ;
US 20050176701 A1
反应条件
pyrrolidine in toluene 24 h; Heating;
参考文献
Breschi, Maria C.; Calderone, Vincenzo; Martelli, Alma; Minutolo, Filippo; Rapposelli, Simona; Testai, Lara; Tonelli, Federica; Balsamo, Aldo
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7600 - 7602
