2′-羟基-5′-溴苯乙酮合成路线 （共 81 条）
反应条件
1: 5'-bromo-2'-hydroxyacetophenone With lithium hexamethyldisilazane in tetrahydrofuran T=-78 - -20°C; 2.5 h; 2: benzoyl chloride in tetrahydrofuran T=-78 - 20°C; 3 h; 3: With sulfuric acid; acetic acid in tetrahydrofuran T=120°C; 0.0833333 h;
参考文献
Chemical Communications, , # 46 p. 4814 - 4816
反应条件
1: pyridine 2: KOH / pyridine 3: H2SO4 / acetic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 15 p. 2003 - 2008
反应条件
1: sodium hydroxide / ethanol / 20 °C 2: copper(l) iodide; oxygen / 48 h / 50 °C / 760.05 Torr / Ionic liquid View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 20 p. 6930 - 6933
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene T=80°C; Baker-Venkataraman rearrangement; 16 h;
参考文献
Abdel Ghani, Sherif B.; Weaver, Louise; Zidan, Zidan H.; Ali, Hussein M.; Keevil, C. William; Brown, Richard C.D.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 518 - 522
反应条件
1: sodium hydroxide / water / Inert atmosphere; Reflux 2: acetic anhydride; sodium acetate / 3.5 h / 140 °C View Scheme
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
反应条件
sodium azide; iodine; sodium hydrogencarbonate in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Rajendar; Kant, Ruchir; Narender
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 18 p. 3591 - 3596
反应条件
potassium carbonate in acetone T=45°C;
参考文献
Shim, Yi Sup; Kim, Ki Chul; Chi, Dae Yoon; Lee, Keun-Hyeung; Cho, Hyeongjin
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2561 - 2563
反应条件
triethylamine; triphenylphosphine; palladium diacetate in benzene 18 h; Heating / reflux;
参考文献
Axys Pharmaceuticals, Inc.
Patent: US6867200 B1, 2005 ;
Location in patent: Page/Page column 62 ;
US 6867200 B1
反应条件
1: 2 h / 80 - 90 °C 2: 72 percent / NH2OH*HCl / ethanol / 0.5 h / Heating View Scheme
参考文献
Synthesis, , # 11 art. no. T14704SS, p. 1845 - 1849
反应条件
pyH(+)CO3(-) in acetic acid
参考文献
Patwari, Shivaji B.; Baseer, Mohammad A.; Vibhute, Yashwant B.; Bhusare, Sudhakar R.
Tetrahedron Letters, 2003 , vol. 44, # 26 p. 4893 - 4894
