2′-羟基-5′-溴苯乙酮合成路线 （共 81 条）
反应条件
1: 92.7 percent / pyridine / 0.58 h
2: 87.1 percent / KOH; pyridine / 0.25 h / 50 °C
3: 94.2 percent / H2SO4; AcOH / 1 h / Heating
4: 84.3 percent / SnCl2 / ethanol / 1 h / Heating
View Scheme
参考文献
Ono, Masahiro; Yoshida, Naoko; Ishibashi, Kenichi; Haratake, Mamoru; Arano, Yasushi; Mori, Hiroshi; Nakayama, Morio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7253 - 7260
反应条件
pyridine; trichlorophosphate
T=0 - 5°C;
参考文献
Mazumdar; Karmakar; Tiwari; Banerjee; Banerji
Journal of the Indian Chemical Society, 1990 , vol. 67, # 10 p. 845 - 847
反应条件
pyridine
0.583333 h;
参考文献
Nagasaki University; Mori, Hiroshi
Patent: EP1815872 A1, 2007 ;
Location in patent: Page/Page column 5; 33; 44; 52 ;
反应条件
pyridine; 1,8-diazabicyclo[5.4.0]undec-7-ene
T=80°C; Baker-Venkataraman rearrangement; 16 h;
参考文献
Abdel Ghani, Sherif B.; Weaver, Louise; Zidan, Zidan H.; Ali, Hussein M.; Keevil, C. William; Brown, Richard C.D.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 2 p. 518 - 522
反应条件
1: 96.5 percent / pyridine / 0.58 h
2: 85.2 percent / KOH; pyridine / 0.25 h / 50 °C
View Scheme
参考文献
Ono, Masahiro; Yoshida, Naoko; Ishibashi, Kenichi; Haratake, Mamoru; Arano, Yasushi; Mori, Hiroshi; Nakayama, Morio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7253 - 7260
反应条件
1: 88 percent / POCl3, pyridine / 0 - 5 °C
2: 1) KOH, pyridine / 2) conc. HCl / 1) 60 deg C, 2h, 2) glacial acetic acid, reflux, 1h
View Scheme
参考文献
Mazumdar; Karmakar; Tiwari; Banerjee; Banerji
Journal of the Indian Chemical Society, 1990 , vol. 67, # 10 p. 845 - 847
反应条件
1: 79 percent
2: 97 percent
View Scheme
参考文献
Sangwan, Naresh K.; Rastogi, Shri Nivas
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 480 - 483
参考文献
Sangwan, Naresh K.; Rastogi, Shri Nivas
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 480 - 483
反应条件
1: 96.5 percent / pyridine / 0.58 h
2: 85.2 percent / KOH; pyridine / 0.25 h / 50 °C
3: 79.4 percent / H2SO4; AcOH / 1 h / Heating
View Scheme
参考文献
Ono, Masahiro; Yoshida, Naoko; Ishibashi, Kenichi; Haratake, Mamoru; Arano, Yasushi; Mori, Hiroshi; Nakayama, Morio
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7253 - 7260
反应条件
1: potassium hydroxide / ethanol; water / 20 °C
2: iodine / dimethyl sulfoxide / |Reflux
View Scheme
参考文献
Sawant; Gill; Nirwan
Indian Journal of Heterocyclic Chemistry, 2012 , vol. 21, # 4 p. 297 - 300
