2'-羟基-5'-硝基苯乙酮合成路线 （共 49 条）
反应条件
1: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr 2: tetrahydrofuran / 0.33 h / 60 °C 3: 71 percent / nitric acid, glacial acetic acid / 2 h / Ambient temperature 4: 96 percent / methanol; H2O / 1 h / 85 °C 5: 90 percent / NaNO2, H2SO4 / ethanol; H2O / 1.) from 0 to 5 deg C, 20 min, 2.) 85 deg C, 20 min, 3.) RT, 1 h View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
参考文献
Allan; Loudon
Journal of the Chemical Society, 1949 , p. 821,824
反应条件
1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 75 °C 2: water / 12 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / methanol / 20 °C / 1034.32 Torr 4: triethylamine / tetrahydrofuran / 48 h / 40 °C View Scheme
参考文献
Joshi, Ramesh A.; Gurjar, Mukund K.; Tripathy, Narendra K.; Chorghade, Mukund S.
Organic Process Research and Development, 2001 , vol. 5, # 2 p. 176 - 178
反应条件
1: hydrogen / 5percent Pd/C / tetrahydrofuran / 2 h / 2068.6 Torr 2: tetrahydrofuran / 0.33 h / 60 °C View Scheme
参考文献
Cushman, Mark; Zhu, Helen; Geahlen, Robert L.; Kraker, Alan J.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3353 - 3362
反应条件
1: KOH 2: Br2 / pyridine 3: pyridine View Scheme
参考文献
Marder, Mariel; Zinczuk, Juan; Colombo, Maria I.; Wasowski, Cristina; Viola, Haydee; Wolfman, Claudia; Medina, Jorge H.; Ruveda, Edmundo A.; Paladini, Alejandro C.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 2003 - 2008
反应条件
1: pyrrolidene / benzene / 20 h / Ambient temperature 2: hydroxylamine hydrochloride / methanol / 10 h / Heating View Scheme
参考文献
Yang, Qing-Chuan; Li, Hong-Ming; Tang, You-Qi; Huang, Wen-Long
Acta Crystallographica Section C: Crystal Structure Communications, 1996 , vol. 52, # 11 p. 2920 - 2922
反应条件
1: sodium acetate 2: aqueous sulfuric acid View Scheme
参考文献
Thanawalla et al.
Journal of the Indian Chemical Society, 1959 , vol. 36, p. 674
反应条件
sodium hydroxide; dihydrogen peroxide T=40°C;
参考文献
Journal of the Chemical Society, , p. 1549,1554
反应条件
sodium ethanolate in ethanol Friedlaender reaction; Reflux;
参考文献
Ma, Ru-Zheng; Yao, Qi-Chao; Yang, Xi; Xia, Min
Journal of Fluorine Chemistry, 2012 , vol. 137, p. 93 - 98
反应条件
1: KOH
2: Br2 / pyridine
3: pyridine
View Scheme
参考文献
Marder, Mariel; Zinczuk, Juan; Colombo, Maria I.; Wasowski, Cristina; Viola, Haydee; Wolfman, Claudia; Medina, Jorge H.; Ruveda, Edmundo A.; Paladini, Alejandro C.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 15 p. 2003 - 2008
