N,N′-二-Boc-硫脲合成路线 （共 9 条）
反应条件
sodium hydride in tetrahydrofuran
参考文献
Poss, Michael A.; Iwanowicz, Edwin; Reid, Joyce A.; Lin, James; Gu, Zhengxiang
Tetrahedron Letters, 1992 , vol. 33, # 40 p. 5933 - 5936
反应条件
1: thiourea With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; 0.333333 h; Inert atmosphere; 2: carbonic acid di-tert-butyl ester in tetrahydrofuran; mineral oil T=0 - 20°C; 3.66667 h; Inert atmosphere;
参考文献
Pierce, Larry T.; Cahill, Michael M.; McCarthy, Florence O.
Tetrahedron, 2011 , vol. 67, # 25 p. 4601 - 4611
反应条件
sodium hydrogencarbonate; thiourea in tetrahydrofuran
参考文献
Oxford, Alexander William; Jack, David
Patent: US2003/36542 A1, 2003 ;
反应条件
sodium hydride in tetrahydrofuran T=20°C; 1 h;
参考文献
Schiavi, Bruno; Ahond, Alain; Poupat, Christiane; Potier, Pierre
Synthetic Communications, 2002 , vol. 32, # 11 p. 1671 - 1674
反应条件
triethylamine; mercury dichloride in N,N-dimethyl-formamide 1.) 5 deg C, 0.5 h, 2.) RT, 18 h;
参考文献
Chand, Pooran; Babu, Yarlagadda S.; Bantia, Shanta; Chu, Naiming; Cole, L. Brent; Kotian, Pravin L.; Laver, W. Graeme; Montgomery, John A.; Pathak, Ved P.; Petty, Sandra L.; Shrout, David P.; Walsh, David A.; Walsh, Gerald M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 4030 - 4052
反应条件
in N,N-dimethyl-formamide
参考文献
Ohara, Keiichiro; Smietana, Michael; Restouin, Audrey; Mollard, Severine; Borg, Jean-Paul; Collette, Yves; Vasseur, Jean-Jacques
Journal of Medicinal Chemistry, 2007 , vol. 50, # 26 p. 6465 - 6475
反应条件
1: in 1,2-dichloro-ethane
T=50°C; 36 h; PS-carbodiimide resin;
2: in 1,2-dichloro-ethane
T=20°C; 24 h;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/41773 A2, 2006 ;
Location in patent: Page/Page column 370-371 ;
WO 2006/041773 A2
反应条件
indole-3-carboxaldehyde-polystyrene resin; sodium cyanoborohydride; dacarbazine; trifluoroacetic acid; tetramethylammonium triacetoxyborohydride
Yield given. Multistep reaction;
参考文献
Estep, Kimberly G.; Neipp, Christopher E.; Stephens Stramiello, Linda M.; Adam, Mavis D.; Allen, Martin P.; Robinson, Shaughnessy; Roskamp, Eric J.
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5300 - 5301
反应条件
Yield given. Multistep reaction;
参考文献
Robinson, Shaughnessy; Roskamp, Eric J.
Tetrahedron, 1997 , vol. 53, # 19 p. 6697 - 6705
