1: 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[(4-oxo-2-pyrimidinyl)amino]-phenyl]benzamide With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=20°C; 2 h; Inert atmosphere; 2: pyridin-3-yl boronic acid With bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane T=20°C; 0.5 h; Inert atmosphere; 3: With sodium carbonate in 1,4-dioxane; water T=100°C; 24 h; Inert atmosphere; Reagent/catalyst;