1: 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in tetrahydrofuran T=50°C; 3.5 h; Inert atmosphere; 2: pyridin-3-yl boronic acid With palladium diacetate; triphenylphosphine in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 3: With sodium carbonate in tetrahydrofuran; water 22 h; Inert atmosphereReflux;