(1S,2S)-反式-N-Boc-2-氨基环戊醇合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated carbon in ethanol
P=1292.9 Torr; 4 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/99276 A1, 2003 ;
Location in patent: Page 267 ;
WO 03/099276 A1
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 1 h;
2: With water in tetrahydrofuran
参考文献
ELI LILLY AND COMPANY; JADHAV, Prabhakar Kondaji; SAEED, Ashraf; GREEN, Jonathan Edward; KRISHNAN, Venkatesh; MATTHEWS, Donald Paul; STEPHENSON, Gregory Alan
Patent: WO2013/55577 A1, 2013 ;
Location in patent: Page/Page column 33 ;
反应条件
1: (1S,2S)-trans-2-azidocyclopentanol With triphenylphosphine in tetrahydrofuran; water
T=20 - 65°C; 6 h;
2: di-tert-butyl dicarbonate With triethylamine in tetrahydrofuran; water
T=20°C; 3 h;
参考文献
Jin, Yonghao; Roycik, Mark D.; Bosco, Dale B.; Cao, Qiang; Constantino, Manuel H.; Schwartz, Martin A.; Sang, Qing-Xiang Amy
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4357 - 4373
反应条件
potassium hydrogencarbonate in diethyl ether; water
96 h; Ambient temperature;
参考文献
Aube; Wolfe; Yantiss; Cook; Takusagawa
Synthetic Communications, 1992 , vol. 22, # 20 p. 3003 - 3012
反应条件
1: 100 percent / Et3N / tetrahydrofuran
2: 96 percent / H2 / Pd-C / ethanol / 6 h / 1292.9 Torr
View Scheme
参考文献
Qiao, Jennifer X.; Chang, Chong-Hwan; Cheney, Daniel L.; Morin, Paul E.; Wang, Gren Z.; King, Sarah R.; Wang, Tammy C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.; Lam, Patrick Y.S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4419 - 4427
反应条件
1: H2 / PtO2
View Scheme
参考文献
Govindaraju; Kumar, Vaijayanti A; Ganesh, Krishna N
Chemical communications (Cambridge, England), 2004 , # 7 p. 860 - 861
