sodium hydroxide; trimethyl-oxonium tetrafluoroborate 1.) CH2Cl2, RT, 2 h, 2.) CH2Cl2, 2.5 h; Yield given. Multistep reaction;

nickel in methanol

<b>Multi-step reaction with 2 steps<br /> </b>1: 86 percent / pyridine, N,N-dimethyl-4-aminopyridine (DMAP) / CH₂Cl₂ / 4 h / Ambient temperature<br />2: 42 percent / 22 h / 0.1 M phosphate buffer (pH 7.0), Pseudomonas sp. (SAM II) lipase<br /> <br /> &nbsp;

22&nbsp;h;&nbsp;&nbsp;0.1 M phosphate buffer (pH 7.0), Pseudomonas sp. (SAM II) lipase;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, a) RT, 1 h, b) reflux, 2 h<br />2: 86 percent / pyridine, N,N-dimethyl-4-aminopyridine (DMAP) / CH₂Cl₂ / 4 h / Ambient temperature<br />3: 42 percent / 22 h / 0.1 M phosphate buffer (pH 7.0), Pseudomonas sp. (SAM II) lipase<br /> <br /> &nbsp;