2-氟-4-硫代氰酰基苯胺合成路线 （共 7 条）
反应条件
bromine; sodium bromide in methanol T=20°C; 0.5 h;
参考文献
Rewcastle, Gordon William; Spicer, Julie Ann; Barrett, Stephen Douglas; Kaufman, Michael David; Milbank, Jared Bruce John; Tecle, Haile
Patent: US2004/6245 A1, 2004 ;
Location in patent: Page 38 ;
反应条件
1: With bromine in acetic acid T=0°C; 1.66667 h; 2: With ammonia in water; acetic acid pH=4;
参考文献
Pharmacia and Upjohn Company LLC
Patent: EP1042295 B1, 2005 ;
Location in patent: Page/Page column 131 ;
反应条件
1: With bromine; sodium bromide in methanol T=-10 - 10°C; 5.33333 h; 2: With sodium carbonate in methanol; water T=0°C;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2174929 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium bromide; bromine; sodium hydrogencarbonate in methanol; water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4632938 A1, 1986 ;
反应条件
bromine in acetic acid
参考文献
Pharmacia and Upjohn Company
Patent: US6093732 A1, 2000 ;
反应条件
1: 4-amino-3-fluorophenyl thiocyanate With sodium sulfide in ethanol; water
T=50°C; 2 h;
2: methyl iodide in ethanol; water
3 h;
参考文献
Novartis AG
Patent: US2009/275606 A1, 2009 ;
Location in patent: Page/Page column 39 ;
US 20090275606 A1
反应条件
sodium hydroxide
T=20 - 60°C;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2174929 A1, 2010 ;
Location in patent: Page/Page column 12-13 ;
