(2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺合成路线 （共 4 条）
反应条件
1: With piperidine in isopropyl alcohol 12 - 15 h; Heating / reflux; 2: With acetic acid in isopropyl alcohol T=20°C;
参考文献
WOCKHARDT LIMITED; JAWEED MUKARRAM, Siddiqui, Mohammed; KHAN, Rashid, Abdul, Rehman; YADAV, Ram, Prasad; SHAIKH, Zakir, Gafoor
Patent: WO2005/66117 A1, 2005 ;
Location in patent: Page/Page column 11 ;
反应条件
pyridine; AlCl3, aluminium chloride in dichloromethane T=0 - 55°C; 3.08333 - 4.25 h;
参考文献
WO2007/94007 A1, ;
Page/Page column 15 ;
反应条件
in toluene 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/94007 A1, ;
Page/Page column 16 ;
反应条件
hydrogenchloride in water; toluene T=7 - 20°C; 4 h; Heating / reflux;
参考文献
PLIVA ISTRAZIVANJE I RAZVOJ D.O.O.; MCLEISH, Nicholas, Alistair, Maxwell
Patent: WO2008/7093 A1, 2008 ;
Location in patent: Page/Page column 9 ;
