N-叔丁氧羰基-L-3-(2-呋喃基)丙氨酸合成路线 （共 14 条）
反应条件
triethylamine in methanol T=60°C; 0.5 h;
参考文献
Berthel, Steven Joseph; Brinkman, John A.; Hayden, Stuart; Haynes, Nancy-Ellen; Kester, Robert Francis; McDermott, Lee Apostle; Qian, Yimin; Sarabu, Ramakanth; Scott, Nathan Robert; Tilley, Jefferson Wright
Patent: US2009/264445 A1, 2009 ;
Location in patent: Page/Page column 38 ;
反应条件
chromic acid in diethyl ether T=20°C; 2 h;
参考文献
Chattopadhyay, Shital K.; Sarkar, Kaushik; Karmakar, Swastik
Synlett, 2005 , # 13 art. no. D11805ST, p. 2083 - 2085
反应条件
1.1: 52 percent / t-BuOK / dimethylformamide / 18 h / 0 - 20 °C 2.1: Grubbs' catalyst / CH2Cl2 / 4 h / 20 °C 2.2: 54 percent / DDQ / benzene / 16 h / Heating 3.1: 82 percent / HCl / methanol / 0.5 h / 0 °C 4.1: 46 percent / aq. H2CrO4 / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Synlett, , # 13 art. no. D11805ST, p. 2083 - 2085
反应条件
1.1: Grubbs' catalyst / CH2Cl2 / 4 h / 20 °C 1.2: 54 percent / DDQ / benzene / 16 h / Heating 2.1: 82 percent / HCl / methanol / 0.5 h / 0 °C 3.1: 46 percent / aq. H2CrO4 / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Synlett, , # 13 art. no. D11805ST, p. 2083 - 2085
反应条件
1.1: 78 percent / 1.5 h / -78 - -20 °C 2.1: 52 percent / t-BuOK / dimethylformamide / 18 h / 0 - 20 °C 3.1: Grubbs' catalyst / CH2Cl2 / 4 h / 20 °C 3.2: 54 percent / DDQ / benzene / 16 h / Heating 4.1: 82 percent / HCl / methanol / 0.5 h / 0 °C 5.1: 46 percent / aq. H2CrO4 / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Synlett, , # 13 art. no. D11805ST, p. 2083 - 2085
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran; methanol T=0°C; 2 h;
参考文献
ChemBioChem, , vol. 11, # 12 p. 1720 - 1726
反应条件
1: 82 percent / HCl / methanol / 0.5 h / 0 °C 2: 46 percent / aq. H2CrO4 / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Synlett, , # 13 art. no. D11805ST, p. 2083 - 2085
反应条件
1: 82 percent / KOH / ethanol; H2O / 3 h / Ambient temperature 2: 80 percent / dioxane / 39 h / Heating 3: 54 percent / KOH / ethanol; H2O / 17 h / Heating 4: 63 percent / cobalt acetate, 25percent aq. NH4OH / H2O / 38 °C / acylase I 5: 1M NaOH / H2O; dioxane View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 1151 - 1158
反应条件
1: 63 percent / cobalt acetate, 25percent aq. NH4OH / H2O / 38 °C / acylase I 2: 1M NaOH / H2O; dioxane View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 1151 - 1158
反应条件
1: 54 percent / KOH / ethanol; H2O / 17 h / Heating 2: 63 percent / cobalt acetate, 25percent aq. NH4OH / H2O / 38 °C / acylase I 3: 1M NaOH / H2O; dioxane View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 1151 - 1158
