1-甲基-4-(2-吡啶基)哌嗪合成路线 （共 6 条）
反应条件
palladium 10 on activated carbon; sodium t-butanolate; 2-dicyclohexylphosphino-1,1'-biphenyl in tert-butyl alcohol T=100°C; Buchwald-Hartwig amination; Inert atmosphere;
参考文献
Komaromi, Anna; Novak, Zoltan
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 9 p. 1523 - 1532
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) 0 deg C, 30 min; room temp., 1 h, 2.) reflux, overnight;
参考文献
Hoeve, Wolter ten; Kruse, Chris, G.; Luteyn, Jan M.; Thiecke, Janet R. G.; Wynberg, Hans
Journal of Organic Chemistry, 1993 , vol. 58, # 19 p. 5101 - 5106
反应条件
Pd-PEPPSI-IPr; potassium tert-butylate in ethylene glycol dimethyl ether T=50°C; Buchwald-Hartwig amination; Inert atmosphere;
参考文献
Organ, Michael G.; Abdel-Hadi, Mirvat; Avola, Stephanie; Dubovyk, Igor; Hadei, Niloufar; Kantchev, Eric Assen B.; O'Brien, Christopher J.; Sayah, Mahmoud; Valente, Cory
Chemistry - A European Journal, 2008 , vol. 14, # 8 p. 2443 - 2452
反应条件
formic acid in ethanol; water 3 h; Heating;
参考文献
Manetti, Dina; Bartolini, Alessandro; Borea, Pier Andrea; Bellucci, Cristina; Dei, Silvia; Ghelardini, Carla; Gualtieri, Fulvio; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 3 p. 457 - 465
反应条件
1: 1-methyl-piperazine With n-butyllithium in tetrahydrofuran; hexane T=0 - 20°C; 0.25 h; 2: 2-pyridine carbonitrile With cesium fluoride in tetrahydrofuran; hexane T=65°C; 47 h; Further stages.;
参考文献
Penney, Jonathan M.
Tetrahedron Letters, 2004 , vol. 45, # 12 p. 2667 - 2669
反应条件
1: pyridine / 155 °C 2: formic acid View Scheme
参考文献
Hamlin et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2731,2732
