1: 93 percent / HgCl2, CaCO3, water / acetonitrile / 7 h / Heating 2: benzene 3: benzene / 3 h / Heating 4: H2, AcOH / 10percent Pd/C / 18 h / 760 Torr / Ambient temperature 5: Et3N / tetrahydrofuran; benzene / 1 h / Ambient temperature 6: 91 percent / NaIO4, KMnO4, KH2PO4, K2HPO4 / H2O; acetone / 3 h / Ambient temperature 7: 80 percent / 4 N HCl in dioxane / 1 h / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11343458', constants.ctx, '0')">dipotassium hydrogenphosphate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11343563', constants.ctx, '0')">potassium dihydrogenphosphate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635680', constants.ctx, '0')">acetone</a> <br />12&nbsp;h;&nbsp;&nbsp;Ambient temperaturelipase PS &quot;Amano&quot;;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 91 percent / benzene / 6.5 h / Heating<br />2: 97 percent / sodium borohydride, cerium(III) chloride heptahydrate / ethanol / 0.67 h<br />3: 95 percent / pyridine / Ambient temperature<br />4: 36 percent / KH₂PO₄, K₂HPO₄, water / acetone / 12 h / Ambient temperature; lipase PS &quot;Amano&quot;<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 97 percent / sodium borohydride, cerium(III) chloride heptahydrate / ethanol / 0.67 h<br />2: 95 percent / pyridine / Ambient temperature<br />3: 36 percent / KH₂PO₄, K₂HPO₄, water / acetone / 12 h / Ambient temperature; lipase PS &quot;Amano&quot;<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 95 percent / pyridine / Ambient temperature<br />2: 36 percent / KH₂PO₄, K₂HPO₄, water / acetone / 12 h / Ambient temperature; lipase PS &quot;Amano&quot;<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1: boron trifluoride etherate / CH₂Cl₂ / 0.67 h / Ambient temperature<br />2: methanol / 4 h / Ambient temperature<br />3: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 40 min, 2.) CH₂Cl₂, from -70 deg C to -5 deg C, 2 h<br />4: 91 percent / benzene / 6.5 h / Heating<br />5: 97 percent / sodium borohydride, cerium(III) chloride heptahydrate / ethanol / 0.67 h<br />6: 95 percent / pyridine / Ambient temperature<br />7: 36 percent / KH₂PO₄, K₂HPO₄, water / acetone / 12 h / Ambient temperature; lipase PS &quot;Amano&quot;<br /> <br /> &nbsp;