1: mCPBA 2: Me2NCOCl / CH2Cl2 3: methanol 4: CH2Cl2 5: 70 percent / KH / CH2Cl2 / Ambient temperature 6: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C 7: imidazole 8: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C 9: MsCl, Et3N 10: CSA / ethanol 11: Dess-Martin periodinane (DMP) 12: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C 13: 98 percent / methanol 14: Dess-Martin periodinane (DMP) 15: NaClO2, NaH2PO4 / various solvent(s) 17: 1) HCO2H, 2) H2O / 2) 140 deg C 18: 3 N KOH / 120 °C View Scheme

1: LiAlH4 2: mCPBA 3: Me2NCOCl / CH2Cl2 4: methanol 5: CH2Cl2 6: 70 percent / KH / CH2Cl2 / Ambient temperature 7: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C 8: imidazole 9: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C 10: MsCl, Et3N 11: CSA / ethanol 12: Dess-Martin periodinane (DMP) 13: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C 14: 98 percent / methanol 15: Dess-Martin periodinane (DMP) 16: NaClO2, NaH2PO4 / various solvent(s) 18: 1) HCO2H, 2) H2O / 2) 140 deg C 19: 3 N KOH / 120 °C View Scheme

1: SOCl2 2: LiAlH4 3: mCPBA 4: Me2NCOCl / CH2Cl2 5: methanol 6: CH2Cl2 7: 70 percent / KH / CH2Cl2 / Ambient temperature 8: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C 9: imidazole 10: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C 11: MsCl, Et3N 12: CSA / ethanol 13: Dess-Martin periodinane (DMP) 14: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C 15: 98 percent / methanol 16: Dess-Martin periodinane (DMP) 17: NaClO2, NaH2PO4 / various solvent(s) 19: 1) HCO2H, 2) H2O / 2) 140 deg C 20: 3 N KOH / 120 °C View Scheme

1: Me2NCOCl / CH2Cl2 2: methanol 3: CH2Cl2 4: 70 percent / KH / CH2Cl2 / Ambient temperature 5: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C 6: imidazole 7: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C 8: MsCl, Et3N 9: CSA / ethanol 10: Dess-Martin periodinane (DMP) 11: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C 12: 98 percent / methanol 13: Dess-Martin periodinane (DMP) 14: NaClO2, NaH2PO4 / various solvent(s) 16: 1) HCO2H, 2) H2O / 2) 140 deg C 17: 3 N KOH / 120 °C View Scheme

1: CH2Cl2 2: 70 percent / KH / CH2Cl2 / Ambient temperature 3: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C 4: imidazole 5: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C 6: MsCl, Et3N 7: CSA / ethanol 8: Dess-Martin periodinane (DMP) 9: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C 10: 98 percent / methanol 11: Dess-Martin periodinane (DMP) 12: NaClO2, NaH2PO4 / various solvent(s) 14: 1) HCO2H, 2) H2O / 2) 140 deg C 15: 3 N KOH / 120 °C View Scheme

1: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C 2: MsCl, Et3N 3: CSA / ethanol 4: Dess-Martin periodinane (DMP) 5: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C 6: 98 percent / methanol 7: Dess-Martin periodinane (DMP) 8: NaClO2, NaH2PO4 / various solvent(s) 10: 1) HCO2H, 2) H2O / 2) 140 deg C 11: 3 N KOH / 120 °C View Scheme

1: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C 2: 98 percent / methanol 3: Dess-Martin periodinane (DMP) 4: NaClO2, NaH2PO4 / various solvent(s) 6: 1) HCO2H, 2) H2O / 2) 140 deg C 7: 3 N KOH / 120 °C View Scheme

1: 1) HCO2H, 2) H2O / 2) 140 deg C 2: 3 N KOH / 120 °C View Scheme