2-甲基-2-硫代异脲硫酸盐合成路线 （共 127 条）
参考文献
Barron,D.I. et al.
J. Med. Chem., 1963 , vol. 6, p. 705 - 711
参考文献
Augstein,J. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 391 - 400
反应条件
phosphorus pentachloride
T=30 - 100°C;
参考文献
Crowther et al.
Journal of the Chemical Society, 1948 , p. 1636,1643
反应条件
1: in water
0.0833333 h; Reflux;
2: With BaCl2 in water
0.5 h; Reflux;
参考文献
Li, Nan; Lim, Reyna K. V.; Edwardraja, Selvakumar; Lin, Qing
Journal of the American Chemical Society, 2011 , vol. 133, # 39 p. 15316 - 15319
反应条件
1: benzimidazole-5,6-dicarboxylic acid anhydride With trimethylsilylazide
T=95°C;
2: S-methylisothiourea sulfate With water in tetrahydrofuran
参考文献
Liu, Haibo; Gao, Jianmin; Kool, Eric T.
Journal of Organic Chemistry, 2005 , vol. 70, # 2 p. 639 - 647
反应条件
sodium hydroxide; triethylamine
T=70 - 80°C; 3 h;
参考文献
Bruno, Olga; Schenone, Silvia; Ranise, Angelo; Bondavalli, Francesco; Barocelli, Elisabetta; Ballabeni, Vigilio; Chiavarini, Milena; Bertoni, Simona; Tognolini, Massimiliano; Impicciatore, Mariannina
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 629 - 636
反应条件
hydrogenchloride; diethyl ether; sodium nitrite
unter Eiskuehlung und bei der Behandlung des Reaktionsgemisches mit verd. NH3 und weiterem S-Methyl-isothioharnstoff-sulfat bei ca. 50grad;
参考文献
Backer; Stedehouder
Recueil des Travaux Chimiques des Pays-Bas, 1933 , vol. 52, p. 930
参考文献
Backer; Stedehouder
Recueil des Travaux Chimiques des Pays-Bas, 1933 , vol. 52, p. 930
参考文献
Braun
Journal of the American Chemical Society, 1933 , vol. 55, p. 1280,1282
参考文献
Schenck; Kirchhof
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 158, # 107 p. 110
