2-甲基-2-硫代异脲硫酸盐合成路线 （共 127 条）
反应条件
1: With sodium hydrogencarbonate in N,N-dimethyl-formamide T=75°C; Biginelli type reaction; 2: With 2-hydroxy-1,3-isoindolinedione; oxygen; [Co(O2CCH3)2]*4H2O in dichloromethane T=80°C; P=760.051 Torr; 1.5 h;
参考文献
Han, Bing; Han, Run-Feng; Ren, Yu-Wei; Duan, Xiao-Yong; Xu, Yi-Chuan; Zhang, Wei
Tetrahedron, 2011 , vol. 67, # 31 p. 5615 - 5620
反应条件
triethylamine in ethanol 2 h; Reflux;
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; KUHN, Daniel; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2014/23385 A1, 2014 ;
Location in patent: Page/Page column 73; 74; 75 ;
反应条件
1: With sodium hydrogencarbonate in N,N-dimethyl-formamide T=75°C; Biginelli type reaction; 2: With 2-hydroxy-1,3-isoindolinedione; oxygen; [Co(O2CCH3)2]*4H2O in dichloromethane T=80°C; P=760.051 Torr; 1 h;
参考文献
Han, Bing; Han, Run-Feng; Ren, Yu-Wei; Duan, Xiao-Yong; Xu, Yi-Chuan; Zhang, Wei
Tetrahedron, 2011 , vol. 67, # 31 p. 5615 - 5620
反应条件
sodium acetate in N,N-dimethyl-formamide T=80 - 90°C; 12 h;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
1: 2-oxosuccinic acid diethyl ester With sodium hydroxide in water 2: S-methylisothiourea sulfate in water 15 h; 3: With hydrogenchloride in water pH=1; 2 h;
参考文献
Ruah, Sara S. Hadida; Hazlewood, Anna R.; Grootenhuis, Peter D. J.; Singh, Ashvani Kumar; Cleveland, Thomas; Van-Goor, Frederick F.
Patent: US2007/105833 A1, 2007 ;
Location in patent: Page/Page column 52 ;
参考文献
Krutovskikh,G.N. et al.
Pharmaceutical Chemistry Journal, 1977 , vol. 11, # 4 p. 484 - 488
Khimiko-Farmatsevticheskii Zhurnal, 1977 , vol. 11, # 4 p. 48 - 52
参考文献
Schuette
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1943 , vol. 279, p. 56
Full Text Show Details
Schering-Kahlbaum A.G.
Patent: DE535070 , 1930 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 3067
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Katiyar, Sanjay Babu; Kumar, Arun; Chauhan, Prem M. S.
Synthetic Communications, 2006 , vol. 36, # 20 p. 2963 - 2973
反应条件
sodium hydroxide T=35°C; 144 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 1 p. 261 - 265
反应条件
1: With sodium carbonate in water T=20°C; 2: pH=8; Alkaline aqueous solution;
参考文献
EXELIXIS, INC.
Patent: WO2007/44698 A1, 2007 ;
Location in patent: Page/Page column 62 ;
WO 2007/044698 A1
