2-甲基-2-硫代异脲硫酸盐合成路线 （共 127 条）
反应条件
sodium acetate in N,N-dimethyl-formamide T=80 - 90°C; 12 h;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
1: S-methylisothiourea sulfate With sodium ethanolate in ethanol T=20°C; 0.5 h; 2: 3-(N,N-dimethylamino)-2-ethoxycarbonylacrolein in ethanol 0.5 h; Heating; Further stages.;
参考文献
Yu-Xiu, Liu; Ming-Bo, Cui; Qi-Qi, Zhao; Qing-Min, Wang; Ying, Liu; Run-Qiu, Huang
Journal of Chemical Research, 2007 , # 8 p. 490 - 493
反应条件
triethylamine in water T=20°C;
参考文献
Liang, Yong-Min; Luo, Sheng-Jun; Zhang, Zhao-Xin; Ma, Yong-Xiang
Synthetic Communications, 2002 , vol. 32, # 1 p. 153 - 157
参考文献
Bannard et al.
Canadian Journal of Chemistry, 1958 , vol. 36, p. 1541,1547
反应条件
potassium carbonate 0.2 h; Microwave irradiation;
参考文献
Goswami, Shyamaprosad; Hazra, Anita; Jana, Subrata
Bulletin of the Chemical Society of Japan, 2009 , vol. 82, # 9 p. 1175 - 1181
参考文献
Schering-Kahlbaum A.G.
Patent: DE576020 , 1927 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 3071
反应条件
sodium acetate in acetic acid 8 h; Heating / reflux;
参考文献
Glaxo Group Limited, Glaxo Group Limited
Patent: WO2004/48344 A1, 2004 ;
Location in patent: Page 17 ;
参考文献
Gen.Aniline and Film Corp.
Patent: US2704710 , 1950 ;
反应条件
1: 4-methyl-3-oxopentanoic acid methyl ester; 4-fluorobenzaldehyde With acetic acid; 3-aminopropionic acid in cyclohexane T=20°C; 20.25 - 24.25 h; Heating / reflux; 2: With sodium carbonate in cyclohexane; water 3: S-methylisothiourea sulfate With 2,3-dicyano-5,6-dichloro-p-benzoquinone Product distribution / selectivity; more than 3 stages;
参考文献
GLENMARK PHARMACEUTICALS LIMITED
Patent: WO2008/59519 A2, 2008 ;
Location in patent: Page/Page column 8; 14-15; 18-20 ;
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=100°C; 24 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/30758 A1, 2005 ;
Location in patent: Page/Page column 58-59 ;
WO 2005/030758 A1
