2-甲基-2-硫代异脲硫酸盐合成路线 （共 127 条）
参考文献
Arndt
Chemische Berichte, 1921 , vol. 54, p. 2239
反应条件
1: 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester With N,N-dimethyl-formamide dimethyl acetal
T=140°C; 1 h;
2: S-methylisothiourea sulfate With sodium ethanolate in ethanol
24 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 91 ;
反应条件
1: N,N-dimethyl-formamide dimethyl acetal; 3-Oxo-pyrrolidine-1-carboxylic acid tert-butyl ester T=20 - 140°C; 1 h;
2: S-methylisothiourea sulfate With sodium ethanolate in ethanol
T=20°C; 24 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1405852 A1, 2004 ;
Location in patent: Page 83 ;
EP 1405852 A1
反应条件
sodium hydroxide in benzene
Heating;
参考文献
Spitzner, Roland; Menzel, Manfred; Schroth, Werner
Synthesis, 1982 , # 3 p. 206 - 210
参考文献
Nemeryuk, M. P.; Sedov, A. L.; Makarov, V. A.; Solov'eva, N. P.; Safonova, T. S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1991 , vol. 27, # 7 p. 804 - 805
Khimiya Geterotsiklicheskikh Soedinenii, 1991 , # 7 p. 999 - 1000
参考文献
Schering-Kahlbaum A.G.
Patent: DE501389 , 1926 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 2339
参考文献
Schering-Kahlbaum A.G.
Patent: DE501389 , 1926 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 2339
反应条件
sodium hydroxide in water
24 h; Ambient temperature;
参考文献
Lipinski, Christopher A.; LaMattina, John L.; Hohnke, Lyle A.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1628 - 1636
参考文献
Barron,D.I. et al.
J. Med. Chem., 1963 , vol. 6, p. 705 - 711
反应条件
1: With sodium hydrogencarbonate in N,N-dimethyl-formamide
T=75°C; Biginelli type reaction;
2: With 2-hydroxy-1,3-isoindolinedione; oxygen; [Co(O2CCH3)2]*4H2O in dichloromethane
T=80°C; P=760.051 Torr; 0.5 h;
参考文献
Han, Bing; Han, Run-Feng; Ren, Yu-Wei; Duan, Xiao-Yong; Xu, Yi-Chuan; Zhang, Wei
Tetrahedron, 2011 , vol. 67, # 31 p. 5615 - 5620
