26,27-二去甲基-1,3-(叔-丁基二甲基硅烷基)(5Z)-骨化三醇24-羧酸甲酯合成路线 （共 9 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; potassium phosphate in tetrahydrofuran; water T=20°C; 1 h;
参考文献
Gogoi, Pranjal; Sigueeiro, Rita; Eduardo, Silvina; Mourino, Antonio
Chemistry - A European Journal, 2010 , vol. 16, # 5 p. 1432 - 1435
反应条件
1H-imidazole in N,N-dimethyl-formamide 2.5 h; Ambient temperature;
参考文献
Chodynski, Michal; Wojciechowska, Wanda; Halkes, Sebastian J.; Van De Velde, Jan-Paul; Kutner, Andrzej
Steroids, 1997 , vol. 62, # 7 p. 546 - 553
反应条件
1: 96 percent / Ph3P, imidazole, I2 / tetrahydrofuran / -20 deg C, 15 min then RT, 1.5 h 2: 90 percent / PDC / CH2Cl2 / 6 h / Ambient temperature 3: 92 percent / LDA / tetrahydrofuran / 2 h / -78 °C 4: 65 percent / CuI, Zn / ethanol; H2O / 0.67 h / sonication 5: 86 percent / Et3N / (Ph3P)2PdCl2 / dimethylformamide / 1 h / 75 °C 6: 97 percent / quinoline, Lindlar catalyst, H2 / hexane / 8 h 7: 96 percent / 2,2,4-trimethyl-pentane / 5 h / Heating; in the dark View Scheme
参考文献
Sestelo, Jose Perez; Mascarenas, Jose L.; Castedo, Luis; Murino, Antonio
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 118 - 123
反应条件
1: 90 percent / PDC / CH2Cl2 / 6 h / Ambient temperature 2: 92 percent / LDA / tetrahydrofuran / 2 h / -78 °C 3: 65 percent / CuI, Zn / ethanol; H2O / 0.67 h / sonication 4: 86 percent / Et3N / (Ph3P)2PdCl2 / dimethylformamide / 1 h / 75 °C 5: 97 percent / quinoline, Lindlar catalyst, H2 / hexane / 8 h 6: 96 percent / 2,2,4-trimethyl-pentane / 5 h / Heating; in the dark View Scheme
参考文献
Sestelo, Jose Perez; Mascarenas, Jose L.; Castedo, Luis; Murino, Antonio
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 118 - 123
反应条件
1: 92 percent / LDA / tetrahydrofuran / 2 h / -78 °C 2: 65 percent / CuI, Zn / ethanol; H2O / 0.67 h / sonication 3: 86 percent / Et3N / (Ph3P)2PdCl2 / dimethylformamide / 1 h / 75 °C 4: 97 percent / quinoline, Lindlar catalyst, H2 / hexane / 8 h 5: 96 percent / 2,2,4-trimethyl-pentane / 5 h / Heating; in the dark View Scheme
参考文献
Sestelo, Jose Perez; Mascarenas, Jose L.; Castedo, Luis; Murino, Antonio
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 118 - 123
反应条件
1: 65 percent / CuI, Zn / ethanol; H2O / 0.67 h / sonication 2: 86 percent / Et3N / (Ph3P)2PdCl2 / dimethylformamide / 1 h / 75 °C 3: 97 percent / quinoline, Lindlar catalyst, H2 / hexane / 8 h 4: 96 percent / 2,2,4-trimethyl-pentane / 5 h / Heating; in the dark View Scheme
参考文献
Sestelo, Jose Perez; Mascarenas, Jose L.; Castedo, Luis; Murino, Antonio
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 118 - 123
反应条件
1: 86 percent / Et3N / (Ph3P)2PdCl2 / dimethylformamide / 1 h / 75 °C 2: 97 percent / quinoline, Lindlar catalyst, H2 / hexane / 8 h 3: 96 percent / 2,2,4-trimethyl-pentane / 5 h / Heating; in the dark View Scheme
参考文献
Sestelo, Jose Perez; Mascarenas, Jose L.; Castedo, Luis; Murino, Antonio
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 118 - 123
反应条件
1: 97 percent / quinoline, Lindlar catalyst, H2 / hexane / 8 h 2: 96 percent / 2,2,4-trimethyl-pentane / 5 h / Heating; in the dark View Scheme
参考文献
Sestelo, Jose Perez; Mascarenas, Jose L.; Castedo, Luis; Murino, Antonio
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 118 - 123
反应条件
1: diethyl ether; tetrahydrofuran / 10 h / Ambient temperature 2: TBAF / tetrahydrofuran / 24 h / Ambient temperature; in the dark View Scheme
参考文献
Sestelo, Jose Perez; Mascarenas, Jose L.; Castedo, Luis; Murino, Antonio
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 118 - 123
