1-苄基-3-乙氧羰基-4-哌啶酮盐酸盐合成路线 （共 23 条）
反应条件
1: water; hydrochloric acid / Behandeln des Reaktionsprodukts mit wss. Natronlauge 2: methanol; barium oxide 3: diethyl ether; lithium alanate View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 31, p. 418,420
反应条件
hydrogenchloride; water Behandeln des Reaktionsprodukts mit wss. Natronlauge;
参考文献
Morosawa
Bulletin of the Chemical Society of Japan, 1958 , vol. 31, p. 418,420
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Bolyard
Journal of the American Chemical Society, 1930 , vol. 52, p. 1030
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Brookes; Walker
Journal of the Chemical Society, 1957 , p. 3173
反应条件
1: sodium alcoholate / ethanol / 2 h / Reflux 2: trichlorophosphate / N,N-dimethyl-formamide / acetonitrile / 3 h / Reflux View Scheme
参考文献
RENOVIS, INC.
Patent: WO2008/123963 A1, 2008 ;
WO 2008/123963 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol; water P=2280 Torr; 24 h; Ambient temperature;
参考文献
Ngo, Anh Ngoc; El Kassimi, Khadija; Amara, Zacharias; Drege, Emmanuelle; Joseph, Delphine
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3296 - 3300
反应条件
sulfuric acid; trichlorophosphate
参考文献
Pars; Granchelli; Razdan; Keller; Teiger; Rosenberg; Harris
Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 445 - 454
反应条件
1: H2SO4, POCl3 2: H2 / Pd-C / ethanol; acetic acid / 2508.2 Torr View Scheme
参考文献
Pars; Granchelli; Razdan; Keller; Teiger; Rosenberg; Harris
Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 445 - 454
反应条件
1: H2SO4, POCl3 2: H2 / Pd-C / ethanol; acetic acid / 2508.2 Torr 3: Na2CO3 / ethanol / Heating View Scheme
参考文献
Pars; Granchelli; Razdan; Keller; Teiger; Rosenberg; Harris
Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 445 - 454
反应条件
1: ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride With hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=760.051 Torr; 15 h; 2: di-tert-butyl dicarbonate With triethylamine in ethanol T=20°C; 16 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/130584 A1, 2008 ;
Location in patent: Page/Page column 131; 135 ;
WO 2008/130584 A1
反应条件
1: 94 percent / hydrogen / palladium on carbon / ethanol / 8 h / atmospheric pressure 2: 89 percent / triethylamine / CH2Cl2 View Scheme
参考文献
Moreno-Manas, Marcial; Perez, Montserrat; Pleixats, Roser
Tetrahedron, 1991 , vol. 50, # 2 p. 515 - 528
反应条件
1: 99 percent / H2 / 10percent Pd/C / ethanol; H2O / 24 h / 2280 Torr / Ambient temperature 2: 96 percent / NaCO3, NaCl / CHCl3; H2O / 12 h / Heating 3: 59 percent / NaOH, NH2OH*HCl / H2O / 1 h / 0 °C 4: 86 percent / H2 / 10percent Pt/C / ethanol / Ambient temperature View Scheme
参考文献
Moreno-Manas, Marcial; Perez, Montserrat; Pleixats, Roser
Tetrahedron, 1991 , vol. 50, # 2 p. 515 - 528
