1-苄基-3-乙氧羰基-4-哌啶酮盐酸盐合成路线 （共 23 条）
反应条件
1: With triethylamine in methanol
T=20°C; 0.166667 h;
2: With sodium tetrahydroborate in methanol
T=20°C; 3 h;
3: With hydrogenchloride; methanol; water; sodium hydrogencarbonate
more than 3 stages;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122258 A1, 2007 ;
Location in patent: Page/Page column 59 ;
反应条件
1: ethanol / 16 h / 120 °C
2: trichlorophosphate / 16 h / 100 °C
View Scheme
参考文献
JANSSEN RandD IRELAND; MC GOWAN, David Craig; RABOISSON, Pierre Jean-Marie Bernard; JONCKERS, Tim Hugo Maria; DAOUBI KHAMLICHI, Mourad
Patent: WO2013/117615 A1, 2013 ;
反应条件
1: 55 g / 72percent H2SO4 / 64 h / Ambient temperature
2: 10.1 g / Potassium carbonate / dimethylformamide / 5 h / 85 - 95 °C
3: 6.1 g / H2 / Pd/C / acetic acid / 2585.7 Torr / Ambient temperature
View Scheme
参考文献
Connor; Unangst; Schwender; et al.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1557 - 1559
