in hexane T=20°C;

1: 30.0 g / borane-dimethyl sulfide complex / diethyl ether / 3.5 h / 0 °C 2: 80 percent / hexane / 20 °C View Scheme

1 h;

in dichloromethane T=0 - 20°C; 0.333333 h; Inert atmosphere;

in dichloromethane T=0 - 20°C; 0.333333 h; Inert atmosphere;

in dichloromethane T=0 - 20°C; 0.333333 h; Inert atmosphere;

1: (1S,2R)-2-(N-benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate With triethylamine in dichloromethane T=20°C; Masamune anti-aldol reaction; Inert atmosphere; 2: dicyclohexylboron triflate in hexane; dichloromethane T=-78°C; Inert atmosphere; 3: (2S,4E)-2,4-dimethyl-5-iodo-4-pentenal Further stages;