(R)-(2-氧代-2,3,4,5-四氢-1H-苯并b氮杂革-3-基)-氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
hydrogen; RuCl2[(S)-BINAP] in ethanol T=60°C; P=2585.7 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Armstrong, Joseph D. III; Eng, Kan K.; Keller, Jennifer L.; Purick, Robert M.; Hartner, Frederick W. Jr.; et al.
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3239 - 3242
参考文献
Merck and Co., Inc.
Patent: US5206235 A1, 1993 ;
反应条件
1: 95 percent / TMSCl, NaI, I2, TMEDA / acetonitrile / -15 °C 2: 95 percent / NaN3 / dimethylformamide / 8 h / 25 °C 3: 1.) KOtBu; 2.) sat. NH4Cl 4: DMAP 5: H2 / (R)-BINAP RuCl2 / methanol / 60 °C / 2068.6 Torr View Scheme
参考文献
Armstrong, Joseph D. III; Eng, Kan K.; Keller, Jennifer L.; Purick, Robert M.; Hartner, Frederick W. Jr.; et al.
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3239 - 3242
反应条件
1: 1.) KOtBu; 2.) sat. NH4Cl 2: DMAP 3: H2 / (R)-BINAP RuCl2 / methanol / 60 °C / 2068.6 Torr View Scheme
参考文献
Armstrong, Joseph D. III; Eng, Kan K.; Keller, Jennifer L.; Purick, Robert M.; Hartner, Frederick W. Jr.; et al.
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3239 - 3242
反应条件
1: 95 percent / NaN3 / dimethylformamide / 8 h / 25 °C 2: 1.) KOtBu; 2.) sat. NH4Cl 3: DMAP 4: H2 / (R)-BINAP RuCl2 / methanol / 60 °C / 2068.6 Torr View Scheme
参考文献
Armstrong, Joseph D. III; Eng, Kan K.; Keller, Jennifer L.; Purick, Robert M.; Hartner, Frederick W. Jr.; et al.
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3239 - 3242
反应条件
hydrogenchloride; water in methanol 1 h;
参考文献
ELI LILLY AND COMPANY
Patent: US2011/144091 A1, 2011 ;
Location in patent: Page/Page column 4-5 ;
