N-Boc-4-碘甲基哌啶合成路线 （共 13 条）
反应条件
pyridine; iodine; triphenylphosphine in benzene 1.5 h; Heating;
参考文献
Villalobos; Blake; Biggers; Butler; Chapin; Chen; Ives; Jones; Liston; Nagel; Nason; Nielsen; Shalaby; White
Journal of Medicinal Chemistry, 1994 , vol. 37, # 17 p. 2721 - 2734
反应条件
lithium iodide in N,N-dimethyl-formamide
反应条件
sodium iodide; triethanolamine in dichloromethane; acetone
参考文献
US6265434 B1, ;
US 6265434 B1
反应条件
1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione in 1,2-dichloro-ethane 2 h; IrradiationInert atmosphereReflux;
参考文献
Kulbitski, Kseniya; Nisnevich, Gennady; Gandelman, Mark
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1438 - 1442
反应条件
1.1: 98 percent / Et3N; DMAP / CH2Cl2 2.1: 94 percent / LiAlH4 / tetrahydrofuran / 0 °C 3.1: Ph3P; imidazole / CH2Cl2 3.2: 74 percent / I2 / CH2Cl2 / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 9 p. 2233 - 2239
反应条件
1.1: 94 percent / LiAlH4 / tetrahydrofuran / 0 °C 2.1: Ph3P; imidazole / CH2Cl2 2.2: 74 percent / I2 / CH2Cl2 / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 9 p. 2233 - 2239
反应条件
1: 94 percent / Et3N / dioxane; H2O / 16 h / 0 - 20 °C 2: 93 percent / LiAlH4 / tetrahydrofuran / 16 h / 0 - 20 °C 3: 92 percent / PPh3, I2, pyridine / benzene / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 17 p. 2721 - 2734
反应条件
sodium iodide in acetone Finkelstein reaction; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 17 p. 5176 - 5197
反应条件
1: dichloromethane 2: iodine; triphenylphosphine; 1H-imidazole View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 12, # 5 p. 783 - 794
反应条件
1: 76 percent / LDA / tetrahydrofuran / 4 h / -78 °C 2: trifluoroacetic acid / CH2Cl2 / 0.5 h / 0 °C 3: Na2CO3 / dimethylformamide / 4 h / Ambient temperature View Scheme
参考文献
Villalobos; Butler; Chapin; Chen; DeMattos; Ives; Jones; Liston; Nagel; Nason; Nielsen; Ramirez; Shalaby; White
Journal of Medicinal Chemistry, 1995 , vol. 38, # 15 p. 2802 - 2808
