叔丁基 3-氧代-环丁烷羧酸合成路线 （共 4 条）
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=25°C; 24 h;
参考文献
Lemieux, Robert P.; Schuster, Gary B.
Journal of Organic Chemistry, 1993 , vol. 58, # 1 p. 100 - 110
反应条件
sulfuric acid; magnesium sulfate in dichloromethane T=20°C; 60 h;
参考文献
WO2004/82682 A1, ;
Page 78 ;
WO 2004/082682 A1
反应条件
sodium tetrahydroborate; ethanol
T=20 - 30°C; 2 h;
参考文献
ABBOTT LABORATORIES; CUSACK, Kevin, P.; BREINLINGER, Eric, C.; FIX-STENZEL, Shannon, R.; STOFFEL, Robert, H.; WOLLER, Kevin, R.
Patent: WO2011/71570 A1, 2011 ;
Location in patent: Page/Page column 162 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol
T=10°C; 1 h; Overall yield = 99 percent; Overall yield = 213 g;
参考文献
Lukin, Kirill; Kishore, Vimal; Gordon, Thomas
Organic Process Research and Development, 2013 , vol. 17, # 4 p. 666 - 671
