1: 64 percent / 50percent NaOH, 40percent Bu4NOH / 4 h / 100 °C 2: 62 percent / hexamethyldisilazane, ISiMe3 / CCl4 / 1) 0 deg C, 2 h, 2) RT, 15 h 3: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h 4: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h View Scheme

1: 64 percent / 50percent NaOH, 40percent Bu4NOH / 4 h / 100 °C 2: 62 percent / hexamethyldisilazane, ISiMe3 / CCl4 / 1) 0 deg C, 2 h, 2) RT, 15 h 3: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h 4: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h View Scheme

1: 64 percent / 50percent NaOH, 40percent Bu4NOH / 4 h / 100 °C 2: 62 percent / hexamethyldisilazane, ISiMe3 / CCl4 / 1) 0 deg C, 2 h, 2) RT, 15 h 3: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h 4: 1) t-BuLi / 1) ether, -70 deg C, 90 min, 2a) ether, -70 deg C, 1 h, 2b) -30 deg C, 1.5 h View Scheme