(R)-3-(3-甲基丁酰)-4-苄基-2-恶唑烷酮合成路线 （共 23 条）
反应条件
1.1: TiCl4 / CH2Cl2 / 0.17 h / 0 °C 1.2: i-Pr2NEt / CH2Cl2 / 1 h / 0 °C 1.3: 95 percent / TiCl4 / CH2Cl2 / 2 h / 0 °C 2.1: 89 percent / CF3SO3H / CH2Cl2; cyclohexane / 2 h / 25 °C View Scheme
参考文献
Boger; Hong
Journal of the American Chemical Society, 2001 , vol. 123, # 35 p. 8515 - 8519
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran 2: 81 percent / LiOH; H2O2 3: 95 percent / LAH / tetrahydrofuran 4: 97 percent / PPh3; NBS / CH2Cl2 5: 68 percent / n-BuLi View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran 2: 81 percent / LiOH; H2O2 3: 95 percent / LAH / tetrahydrofuran 4: 97 percent / PPh3; NBS / CH2Cl2 5: 68 percent / n-BuLi 6: HCl / acetonitrile 7: Et3N 8: LiOH / methanol; H2O 9: EDCI; HOBt View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 94 percent / LIHMDS / tetrahydrofuran / -78 °C 2: 88 percent / OsO4; NMMO / 2-methyl-propan-2-ol; acetone; H2O 3: NaIO4; RuCl3*H2O / CCl4; acetonitrile; H2O / 6 h 4: (COCl)2 / dimethylformamide; toluene / 1 h 5: NEt3 / CH2Cl2 6: 100 percent / H2 / Pd/C / ethyl acetate 7: (COCl)2 / toluene; dimethylformamide / 1 h 8: Mg; BrCH2CH2Br / tetrahydrofuran / 20 °C 9: H2 / [Ru2Cl4((S)-BINAP)]NEt3 / methanol / 40 h / 40 °C / 37503 Torr 10: NEt3 / CH2Cl2 11: 85 percent / NaN3; 15-crown-6; DMPU 12: 59 percent / 2-OH-pyridine; NEt3 View Scheme
参考文献
Rueger; Stutz; Goschke; Spindler; Maibaum
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10085 - 10089
反应条件
1.1: lithium hexamethyldisilazane 2.1: sodium periodate; osmium(VIII) oxide / 0 - 20 °C 3.1: dicyclohexyl(trifluoromethylsulfonyloxy)borane; triethylamine / -78 - 0 °C 4.1: dihydrogen peroxide; lithium hydroxide hydrate / tetrahydrofuran; water / 0.25 h 4.2: Acidic aq. solution 5.1: water; lithium hydroxide hydrate / 1,4-dioxane / 120 h / 40 °C 6.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.33 h / 20 °C 7.1: diphenyl phosphoryl azide; triethylamine / toluene / 1 h / 65 °C 8.1: 1.5 h / 65 °C 9.1: 2-hydroxy-pyridine / tert-butyl methyl ether / 65 °C View Scheme
参考文献
Slade, Joel; Liu, Hui; Prashad, Mahavir; Prasad, Kapa
Tetrahedron Letters, 2011 , vol. 52, # 33 p. 4349 - 4352
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran 2: 81 percent / LiOH; H2O2 3: 95 percent / LAH / tetrahydrofuran 4: 97 percent / PPh3; NBS / CH2Cl2 View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran 2: 81 percent / LiOH; H2O2 3: 95 percent / LAH / tetrahydrofuran 4: 97 percent / PPh3; NBS / CH2Cl2 5: 68 percent / n-BuLi 6: HCl / acetonitrile 7: Et3N 8: NaBH4 / ethanol 9: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran 2: 81 percent / LiOH; H2O2 3: 95 percent / LAH / tetrahydrofuran View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 50 percent / TiCl4 / CH2Cl2 2: 82 percent / LiOH; H2O2 3: 86 percent / LAH / tetrahydrofuran 4: 61 percent / PPh3; NBS / CH2Cl2 View Scheme
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
反应条件
1: 76 percent / LiHMDS / tetrahydrofuran
2: 81 percent / LiOH; H2O2
3: 95 percent / LAH / tetrahydrofuran
4: 97 percent / PPh3; NBS / CH2Cl2
5: 68 percent / n-BuLi
6: HCl / acetonitrile
7: Et3N
8: NaBH4 / ethanol
View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
